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A Tribute to Lewis Wolpert on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis

Version 1 : Received: 19 November 2019 / Approved: 20 November 2019 / Online: 20 November 2019 (10:31:55 CET)

How to cite: Durston, A. A Tribute to Lewis Wolpert on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis. Preprints 2019, 2019110236 (doi: 10.20944/preprints201911.0236.v1). Durston, A. A Tribute to Lewis Wolpert on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis. Preprints 2019, 2019110236 (doi: 10.20944/preprints201911.0236.v1).

Abstract

This article is a tribute to Lewis Wolpert on the occasion of the recent 50th anniversary of the publication of his article ‘Positional Information and the Spatial Pattern of Differentiation’. This tribute relates to another of his ideas: his early ‘Progress Zone’ timing model for limb development. Recent evidence is reviewed that a mechanism sharing features with this model patterns the main body axis in early vertebrate development. This tribute celebrates the golden era of Developmental Biology.

Subject Areas

Hox genes; limb development; main body axis; timing; time space translation

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