Working Paper Article Version 1 This version is not peer-reviewed

Interstitial MR Lymphography with Superparamagnetic Iron Oxide for Sentinel Lymph Node Mapping of Clinically N0 Early Oral Cancer: A Prospective Comparative Study with CT Lymphography

Version 1 : Received: 10 November 2019 / Approved: 14 November 2019 / Online: 14 November 2019 (09:10:59 CET)

How to cite: Sugiyama, S.; Iwai, T.; Baba, J.; Oguri, S.; Izumi, T.; Sekino, M.; Kusakabe, M.; Mitsudo, K. Interstitial MR Lymphography with Superparamagnetic Iron Oxide for Sentinel Lymph Node Mapping of Clinically N0 Early Oral Cancer: A Prospective Comparative Study with CT Lymphography. Preprints 2019, 2019110152 Sugiyama, S.; Iwai, T.; Baba, J.; Oguri, S.; Izumi, T.; Sekino, M.; Kusakabe, M.; Mitsudo, K. Interstitial MR Lymphography with Superparamagnetic Iron Oxide for Sentinel Lymph Node Mapping of Clinically N0 Early Oral Cancer: A Prospective Comparative Study with CT Lymphography. Preprints 2019, 2019110152

Abstract

The purpose of this prospective study was to evaluate the usefulness of interstitial magnetic resonance lymphography (MRL) with superparamagnetic iron oxide (SPIO) in sentinel lymph node (SLN) mapping of clinically N0 early oral cancer, and to conduct a comparative study of this MRL with computed tomography lymphography (CTL). CTL and MRL was performed for SLN mapping before surgery for 24 patients with clinically N0 early oral cancer. SLNs were detected by CTL in 21 (87.5%) patients, and the total and mean number of SLN were 45 and 1.9, respectively. All SLNs could be detected 2 min and 3.5-5 min after contrast medium injection. In all patients, SLNs were detected by MRL at 10 min after SPIO injection, and the total and mean number of SLN was 66 and 2.8, respectively. MRL at 30 min after the injection showed additional 2 secondary lymph nodes. Interstitial MRL with SPIO is safe and useful imaging for detection of SLNs in clinically N0 early oral cancer, and the optimal imaging timing is 10 min after SPIO injection.

Subject Areas

computed tomography lymphography; early oral cancer; magnetic resonance lymphography; metastasis; sentinel lymph node; superparamagnetic iron oxide

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.