Version 1
: Received: 20 September 2019 / Approved: 21 September 2019 / Online: 21 September 2019 (09:51:28 CEST)
How to cite:
Nadheer, K.N.; Zahraei, Z.; Al-Hakeim, H. Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia. Preprints2019, 2019090252. https://doi.org/10.20944/preprints201909.0252.v1
Nadheer, K.N.; Zahraei, Z.; Al-Hakeim, H. Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia. Preprints 2019, 2019090252. https://doi.org/10.20944/preprints201909.0252.v1
Nadheer, K.N.; Zahraei, Z.; Al-Hakeim, H. Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia. Preprints2019, 2019090252. https://doi.org/10.20944/preprints201909.0252.v1
APA Style
Nadheer, K.N., Zahraei, Z., & Al-Hakeim, H. (2019). Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia. Preprints. https://doi.org/10.20944/preprints201909.0252.v1
Chicago/Turabian Style
Nadheer, K.N., Zohreh Zahraei and Hussein Al-Hakeim. 2019 "Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia" Preprints. https://doi.org/10.20944/preprints201909.0252.v1
Abstract
Preeclampsia (PE) is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction and the impairment of placenta vascular endothelial integrity. This study aimed to investigate the effect of serum copper (Cu) level on some angiogenesis-related factors including vascular endothelial growth factor-A (VEGF-A), soluble Fms-like tyrosine kinase-1 (sVEGF-R1), soluble endoglin (sEng) and cerruloplasmin (Cp) in Iraqi women with preeclampsia (PE) and control pregnant women. Therefore, 60 women with PE in addition to 30 healthy pregnant women were enrolled in the study. Serum concentration of sEng, VEGF-A, sVEGF-R1, and Cu in PE group significantly increased (p<0.05) in the PE group compared with that in the control group. Increased production of antiangiogenic factors, soluble VEGF-A and sEng contribute to the pathophysiology of PE, indicating the involvement of these parameters in the angiogenic balance in patients with PE. Tests for between-subject effects showed that the circulating angiogenesis factors and Cu were significantly associated with the presence of PE. Serum Cu level was significantly correlated with VEGF- A and VEGF-R1 levels but not with sEng. Multiple regression analysis revealed that only Cp and BP can significantly predict the complications in women with PE. In conclusion, serum Cu has a role in the angiogenesis in women with PE and may be a new drug target in the prevention or treatment of PE.
Keywords
copper; endoglin; preeclampsia; VEGF-A; sVEGF-R1
Subject
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
