Preprint Article Version 1 This version is not peer-reviewed

ARSA-16S: A New and Conceptually Different Approach for 16S-based Taxonomic Profiling

Version 1 : Received: 12 September 2019 / Approved: 16 September 2019 / Online: 16 September 2019 (16:41:43 CEST)

How to cite: Pareja-Tobes, E.; Tobes, R. ARSA-16S: A New and Conceptually Different Approach for 16S-based Taxonomic Profiling. Preprints 2019, 2019090170 (doi: 10.20944/preprints201909.0170.v1). Pareja-Tobes, E.; Tobes, R. ARSA-16S: A New and Conceptually Different Approach for 16S-based Taxonomic Profiling. Preprints 2019, 2019090170 (doi: 10.20944/preprints201909.0170.v1).

Abstract

Here we describe ARSA-16S, a tool and accompanying reference database for the analysis of bacterial 16S amplicons. Among other features, ARSA-16S is based on a new model, approach, and algorithm for sequence-level assignment of reads understood as probability distributions, assigns reads individually, and is designed with non-overlapping amplicons covering two non-contiguous regions. A new set of primers for the amplification and sequencing of the V4 and V6 regions is also provided.

Subject Areas

16S analysis, metagenomics, amplicons, bioinformatics, DNA sequencing

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