In Schizophrenia, PON1 Q192R Genotypes and/or Lowered Paraoxonase 1 (PON1) Enzymatic Activity are Significantly Associated with the Deficit Syndrome, Negative Symptoms, Formal Thought Disorders, Psychomotor Retardation, Excitation and Increased IgA Levels to Gram-Negative Microbiota

Andressa Keiko Matsumoto; Michael Maes; Annabel Maes; Ana Paula Michelin; Laura de Oliveira Semeão; João Victor de Lima Pedrão; Estefania Moreira; Buranee Kanchanatawan; Decio S. Barbosa

doi:10.20944/preprints201909.0095.v1

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preprints.org > medicine and pharmacology > psychiatry and mental health > doi: 10.20944/preprints201909.0095.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In Schizophrenia, PON1 Q192R Genotypes and/or Lowered Paraoxonase 1 (PON1) Enzymatic Activity are Significantly Associated with the Deficit Syndrome, Negative Symptoms, Formal Thought Disorders, Psychomotor Retardation, Excitation and Increased IgA Levels to Gram-Negative Microbiota

Andressa Keiko Matsumoto

Michael Maes

^* ,

Annabel Maes

Ana Paula Michelin

Laura de Oliveira Semeão

João Victor de Lima Pedrão

Estefania Moreira

Buranee Kanchanatawan

Decio S. Barbosa

Version 1 : Received: 8 September 2019 / Approved: 9 September 2019 / Online: 9 September 2019 (09:00:44 CEST)

How to cite: Matsumoto, A.K.; Maes, M.; Maes, A.; Michelin, A.P.; de Oliveira Semeão, L.; de Lima Pedrão, J.V.; Moreira, E.; Kanchanatawan, B.; Barbosa, D.S. In Schizophrenia, PON1 Q192R Genotypes and/or Lowered Paraoxonase 1 (PON1) Enzymatic Activity are Significantly Associated with the Deficit Syndrome, Negative Symptoms, Formal Thought Disorders, Psychomotor Retardation, Excitation and Increased IgA Levels to Gram-Negative Microbiota. Preprints 2019, 2019090095. https://doi.org/10.20944/preprints201909.0095.v1 Matsumoto, A.K.; Maes, M.; Maes, A.; Michelin, A.P.; de Oliveira Semeão, L.; de Lima Pedrão, J.V.; Moreira, E.; Kanchanatawan, B.; Barbosa, D.S. In Schizophrenia, PON1 Q192R Genotypes and/or Lowered Paraoxonase 1 (PON1) Enzymatic Activity are Significantly Associated with the Deficit Syndrome, Negative Symptoms, Formal Thought Disorders, Psychomotor Retardation, Excitation and Increased IgA Levels to Gram-Negative Microbiota. Preprints 2019, 2019090095. https://doi.org/10.20944/preprints201909.0095.v1

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MDPI and ACS Style

Matsumoto, A.K.; Maes, M.; Maes, A.; Michelin, A.P.; de Oliveira Semeão, L.; de Lima Pedrão, J.V.; Moreira, E.; Kanchanatawan, B.; Barbosa, D.S. In Schizophrenia, PON1 Q192R Genotypes and/or Lowered Paraoxonase 1 (PON1) Enzymatic Activity are Significantly Associated with the Deficit Syndrome, Negative Symptoms, Formal Thought Disorders, Psychomotor Retardation, Excitation and Increased IgA Levels to Gram-Negative Microbiota. Preprints 2019, 2019090095. https://doi.org/10.20944/preprints201909.0095.v1

APA Style

Matsumoto, A.K., Maes, M., Maes, A., Michelin, A.P., de Oliveira Semeão, L., de Lima Pedrão, J.V., Moreira, E., Kanchanatawan, B., & Barbosa, D.S. (2019). In Schizophrenia, PON1 Q192R Genotypes and/or Lowered Paraoxonase 1 (PON1) Enzymatic Activity are Significantly Associated with the Deficit Syndrome, Negative Symptoms, Formal Thought Disorders, Psychomotor Retardation, Excitation and Increased IgA Levels to Gram-Negative Microbiota. Preprints. https://doi.org/10.20944/preprints201909.0095.v1

Chicago/Turabian Style

Matsumoto, A.K., Buranee Kanchanatawan and Decio S. Barbosa. 2019 "In Schizophrenia, PON1 Q192R Genotypes and/or Lowered Paraoxonase 1 (PON1) Enzymatic Activity are Significantly Associated with the Deficit Syndrome, Negative Symptoms, Formal Thought Disorders, Psychomotor Retardation, Excitation and Increased IgA Levels to Gram-Negative Microbiota" Preprints. https://doi.org/10.20944/preprints201909.0095.v1

Abstract

Background: Primary deficit schizophrenia (DS) is characterized by enduring negative symptoms and represents a qualitatively different disease entity with respect to non-deficit schizophrenia (NDS). No studies investigated the association between the enzyme paraoxonase 1 (PON1) and DS and its phenomenology. Methods: In this case-control study, Thai women and men, aged 18-65 years, were divided in DS (n=40) and NDS (n=40) and were compared to controls (n=40). PON1 activities against 4-(chloromethyl)phenyl acetate (CMPA) and phenylacetate were determined. Moreover, subjects were genotyped for their PON1 Q192R polymorphism and IgA levels responses directed to Gram-negative bacteria were measured. Results: DS is significantly associated with the QQ genotype and the Q allele as compared with NDS and controls. PON1 activities are significantly and inversely associated with negative symptoms, formal thought disorders, psychomotor retardation, excitation and DS. The presence of the Q allele is associated with increased IgA responses to Pseudomonas aeruginosa, Morganella morganii, and Pseudomonas putida as compared with RR carriers. Conclusions: The PON1 Q allele and lower PON1 activities especially against CMPA are associated with DS, indicating lowered quorum quenching abilities as well as lowered defenses against lipoperoxidation and immune activation. It is suggested that lowered PON1 activity in DS constitutes an impairment in the innate immune system which together with lowered natural IgM may cause lower immune regulation thereby predisposing towards greater neurotoxic effects of immune-inflammatory, oxidative and nitrosative pathways and Gram-negative microbiota.

Keywords

deficit schizophrenia; antioxidants; bacteria; neuro-immune; inflammation; oxidative and nitrosative stress

Subject

Medicine and Pharmacology, Psychiatry and Mental Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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