Preprint Article Version 1 This version is not peer-reviewed

Evaluation of Magnetic Parameters and Kinetics of the Magnetic Nanoparticles in High Magnetic Fields

Version 1 : Received: 2 September 2019 / Approved: 3 September 2019 / Online: 3 September 2019 (16:28:33 CEST)

How to cite: Arokiaraj, M.C.; Liubimtcev, A. Evaluation of Magnetic Parameters and Kinetics of the Magnetic Nanoparticles in High Magnetic Fields. Preprints 2019, 2019090035 (doi: 10.20944/preprints201909.0035.v1). Arokiaraj, M.C.; Liubimtcev, A. Evaluation of Magnetic Parameters and Kinetics of the Magnetic Nanoparticles in High Magnetic Fields. Preprints 2019, 2019090035 (doi: 10.20944/preprints201909.0035.v1).

Abstract

Background: Multifunctional nanoparticles are known for their wide range of biomedical applications. Controlling the magnetic properties of these nanoparticles is imperative for various applications, including therapeutic angiogenesis. The study was performed to evaluate the magnetic properties and their control mechanisms by the external magnetic field. Methods: A 100nm magnetic nanoparticle was placed in the magnetic field, and parametrically the magnet field strength and distance was evaluated. Various models of magnetic strength and disposition were evaluated. Magnetic flux density, force/weight, and magnetic gradient strength were the parameters evaluated in electromagnetic computational software. Results: The seven-coil method with three centrally placed coils as Halbach array, and each coil with a flux density of 7 Tesla, and with a coil dimension of 20cmx20cm (square model) of each coil showed a good magnetic strength and force/weight parameters in a distance of 15cm from the centrally placed coil. The particles were then evaluated for their motion characteristics in saline. It showed good displacement and acceleration properties. After that, the particles were theoretically assessed in a similar mathematical model after parametrically correcting the drag force. After application of high drag forces, the particles showed adequate motion characteristics. When the particle size was reduced further, the motion characteristics were preserved even with high drag forces. Conclusion: There is potential for a novel method of controlling multifunctional magnetic nanoparticles using high magnetic fields. Further studies are required to evaluate the motion characteristics of these particles in-vivo and invitro.

Supplementary and Associated Material

Subject Areas

Magnetic nanoparticles, High magnetic fields, Electromagnetic finite element analysis, Angiogenesis, Tissue engineering, Halbach array

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