Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Evaluation of In-Vitro Release Kinetic and Mechanisms of Curcumin Loaded-Cockle Shell-Derived Calcium Carbonate Nanoparticles

Maryam Muhammad Mailafiya
* ORCID logo ,
Kabeer Abubakar
ORCID logo ,
Abubakar Danmaigoro
ORCID logo ,
Samaila Musa Chiroma
ORCID logo ,
Ezamin Bin Abdul Rahim
,
Mohamad Aris Mohd Moklas
* ORCID logo ,
Zuki Abu Bakar Zakaria
Version 1 : Received: 25 August 2019 / Approved: 25 August 2019 / Online: 25 August 2019 (15:47:58 CEST)

How to cite: Muhammad Mailafiya, M.; Abubakar, K.; Danmaigoro, A.; Musa Chiroma, S.; Bin Abdul Rahim, E.; Aris Mohd Moklas, M.; Abu Bakar Zakaria, Z. Evaluation of In-Vitro Release Kinetic and Mechanisms of Curcumin Loaded-Cockle Shell-Derived Calcium Carbonate Nanoparticles. Preprints 2019, 2019080254. https://doi.org/10.20944/preprints201908.0254.v1 Muhammad Mailafiya, M.; Abubakar, K.; Danmaigoro, A.; Musa Chiroma, S.; Bin Abdul Rahim, E.; Aris Mohd Moklas, M.; Abu Bakar Zakaria, Z. Evaluation of In-Vitro Release Kinetic and Mechanisms of Curcumin Loaded-Cockle Shell-Derived Calcium Carbonate Nanoparticles. Preprints 2019, 2019080254. https://doi.org/10.20944/preprints201908.0254.v1

Abstract

Curcumin has restrained clinical applications due to poor bioavailability. This study aimed to synthesize cockle shell-derived calcium carbonate (aragonite) nanoparticles (CSCaCO3NP) for delivery of curcumin and to evaluate its kinetic release in vitro. CSCaCO3NP was synthesized and conjugated with curcumin (Cur-CSCaCO3NP) using a simple top down approach and characterized for its physicochemical properties as a potential curcumin carrier. In vitro release profile was assessed using dialysis bag membrane method. The release data were fitted to Korsmeyer-Peppas, Zero order and Higuchi models to evaluate the mechanism of release pattern. A spherical shaped CSCaCO3NP with a surface area of 14.48±0.1 m2/g, average mean diameter size of 21.38±2.7 nm and a zeta potential of -18.7 mV was synthesized which has a high loading content and encapsulation efficiency. The FT-IR and XRD revealed less observable changes on the peaks after conjugation. In vitro kinetic release profile demonstrated sustained release and best fitted to the Higuchi equation model. The results of this study showed the capacity of the synthesized CSCaCO3NP to encapsulate curcumin efficiently with a stable release in vitro. This could give an insight and supportive ideas on the potentials of CSCaCO3NP for curcumin delivery. Therefore, CSCaCO3NP holds future prospects in preclinical framework to enhance curcumin efficacy for oral therapeutic applications.

Keywords

cockleshell; nanoparticles; curcumin; aragonite; therapeutics; kinetic release

Subject

Chemistry and Materials Science, Applied Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.