Preprint Article Version 1 This version is not peer-reviewed

Antiproliferative Activity of Cucurbitaceae Species Extracts from Southeast of Mexico

Version 1 : Received: 10 August 2019 / Approved: 11 August 2019 / Online: 11 August 2019 (08:50:51 CEST)

How to cite: Morales-Vela, K.; Pérez-Sánchez, F.C.; Padron, J.M.; Márquez-Fernández, O. Antiproliferative Activity of Cucurbitaceae Species Extracts from Southeast of Mexico. Preprints 2019, 2019080127 (doi: 10.20944/preprints201908.0127.v1). Morales-Vela, K.; Pérez-Sánchez, F.C.; Padron, J.M.; Márquez-Fernández, O. Antiproliferative Activity of Cucurbitaceae Species Extracts from Southeast of Mexico. Preprints 2019, 2019080127 (doi: 10.20944/preprints201908.0127.v1).

Abstract

There are many species of endemic plants from Mexico, without food or commercial use, but with different applications in traditional medicine and valuable for their content of secondary metabolites. In this sense, we found two species of Cucurbitacea family plants natives of southeast and gulf of México, with traditionally use how soap and laundry agent, control of some pests, and it has also been used how infusion for the treatment of different types of dermatitis and stomachache. In the present work, we evaluate the antiproliferative activity in vitro, of six crude organic extracts, tested against six human tumor cell lines, A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), T-47D (breast) and WiDr (colon), the results indicated that at least three extracts from both species presents an interesting antiproliferative activity on five tumor cell lines.

Subject Areas

Cucurbitaceae; cucurbitacines; triterpenic saponines; cell cancer lines; antiproliferative activities

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