Preprint Article Version 1 This version is not peer-reviewed

Design of Controlled Release System for Paracetamol Based on Modified Lignin

Version 1 : Received: 23 May 2019 / Approved: 24 May 2019 / Online: 24 May 2019 (12:40:01 CEST)

A peer-reviewed article of this Preprint also exists.

Pishnamazi, M.; Hafizi, H.; Shirazian, S.; Culebras, M.; Walker, G.M.; Collins, M.N. Design of Controlled Release System for Paracetamol Based on Modified Lignin. Polymers 2019, 11, 1059. Pishnamazi, M.; Hafizi, H.; Shirazian, S.; Culebras, M.; Walker, G.M.; Collins, M.N. Design of Controlled Release System for Paracetamol Based on Modified Lignin. Polymers 2019, 11, 1059.

Journal reference: Polymers 2019, 11, 1059
DOI: 10.3390/polym11061059

Abstract

The influence of lignin modification on drug release and pH-dependent releasing behaviour of oral solid dosage form was investigated using three different formulations. The first formulation contains microcrystalline cellulose (MCC101) as excipient and paracetamol as active pharmaceutical ingredient (API). The second formulation includes Alcell lignin and MCC 101 as excipient and paracetamol, and the third formulation consists of carboxylated Alcell lignin, MCC 101 and paracetamol. Direct compaction was carried out in order to prepare the tablets. Lignin can be readily chemically modified due to the existence of different functional groups in its structure. The focus of this investigation is on lignin carboxylation and its influence on paracetamol control release behaviour at varying pH. Results suggest that carboxylated lignin tablets had the highest drug release, which is linked to their faster disintegration and lower tablet hardness.

Subject Areas

lignin; drug release; paracetamol; disintegration

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