Preprint Article Version 1 This version is not peer-reviewed

Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogues, and Preparation of Hydrogel via Click Chemistry

Version 1 : Received: 13 March 2019 / Approved: 14 March 2019 / Online: 14 March 2019 (08:50:40 CET)

How to cite: Shang, P.; Wu, J.; Shi, X.; Wang, Z.; Song, F.; Liu, S. Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogues, and Preparation of Hydrogel via Click Chemistry. Preprints 2019, 2019030151 Shang, P.; Wu, J.; Shi, X.; Wang, Z.; Song, F.; Liu, S. Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogues, and Preparation of Hydrogel via Click Chemistry. Preprints 2019, 2019030151

Abstract

The cross-linkable PCL-PEG analogues block-graft copolymer was designed and synthesized, which with the copolymer of the MEO2MA and OEGMA as graft chains to improve the mPEG-b-PCL-b-mPEG copolymer the aqueous solution properties. And successfully prepared two hydrogels via a copper-catalyzed 1, 3-dipolar azide-alkyne cycloaddition reaction of alkyne-terminated poly[glycidyl methacrylate-co-2-(2-methoxyethoxy) ethyl methacrylate-co-oligo (ethylene glycol) methacrylate] [P(GMA-co-MEO2MA-co-OEGMA)] with azide end-functionalized PCL-PEG analogues block-graft copolymer, and tetrakis (2-propynyloxymethyl) -methane (TPOM) and with azide end-functionalized PCL-PEG analogues block-graft copolymer. The copolymer's chemical structure was characterized by proton nuclear magnetic resonance spectroscopy and fourier transform infrared spectroscopy. The molecular weights of the copolymers were decided with gel permeation chromatography. The water solubility and temperature sensitivity of the copolymers were studied by taking digital photos and transmittance change measured by UV spectrophotometer at different temperatures. Fluorescence probes, surface tension, dynamic light scattering and transmission electron microscopy were used to analyze the micelles that copolymers self-assembly in aqueous solution. The sol-gel behavior of copolymer solutions at high concentrations was explored by vial inversion experiments. Finally, the network structure of the gels was observed by scanning electron microscopy. These conclusions indicate that these hydrogels are expected to be used as a new material in the field of biomedicine.

Subject Areas

ε-Caprolactone; block-graft copolymer; click chemistry; hydrogel

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