Preprint Article Version 2 This version is not peer-reviewed

How Does Contrast Media Affect Cardiac Markers and Coagulation Tests? Experimental Study

Version 1 : Received: 16 January 2019 / Approved: 17 January 2019 / Online: 17 January 2019 (03:10:04 CET)
Version 2 : Received: 18 January 2019 / Approved: 20 January 2019 / Online: 20 January 2019 (10:40:23 CET)

How to cite: Tascanov, M.B.; Gönel, A. How Does Contrast Media Affect Cardiac Markers and Coagulation Tests? Experimental Study. Preprints 2019, 2019010172 (doi: 10.20944/preprints201901.0172.v2). Tascanov, M.B.; Gönel, A. How Does Contrast Media Affect Cardiac Markers and Coagulation Tests? Experimental Study. Preprints 2019, 2019010172 (doi: 10.20944/preprints201901.0172.v2).

Abstract

Background and objectives: The fact that the results of troponin and Nt-proBNP interfere from biotin caused some commercial firms to update their measurement methods. In particular, the clinical incompatibility of cardiac test results may affect the risk of morbidity and mortality. The aim of this study is to investigate the interference effects of 7 different contrast agents on cardiac markers (Troponin-I, Nt-proBNP, Mass CK-MB, CK, AST, LDH) and coagulation tests (PT, APTT). Materials and Methods: Seven different contrast medias were added into control materials by using interference protocol. Concentration of PT, APTT, CK, AST, LDH, Mass CK-MB, Troponin-I, Nt-proBNP were measured by Sysmex CS-2100, Abbott c16000, Siemens Centaur XP and AFİAS-6 analyzer. The amount of deviations from target values were calculated. Results: 7 different contrast medias caused negative interference in troponin levels between 57.43% and 62.87%. It was found that different contrast medias produced false negativity in the Nt-proBNP test ranging from 6.11% to 96.01%. Enzymes and coagulation tests have been less affected. Conclusions: Different contrast medias may cause false negative cTnI and Nt-proBNP. Therefore, the contrast medias which causes the least interference should be preferred. The results of samples taken in the first hour of contrast imaging should be interpreted with care.

Subject Areas

contrast media; troponin; Nt-proBNP; interference

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.