Version 1
: Received: 3 January 2019 / Approved: 4 January 2019 / Online: 4 January 2019 (14:32:38 CET)
How to cite:
Mierzwa, M.; Krysinski, P.; Bilewicz, R. Hybrid delivery systems for methotrexate-lipidic liquid crystalline cubic phases and cubosomes with magnetic nanoparticles. Preprints2019, 2019010046. https://doi.org/10.20944/preprints201901.0046.v1
Mierzwa, M.; Krysinski, P.; Bilewicz, R. Hybrid delivery systems for methotrexate-lipidic liquid crystalline cubic phases and cubosomes with magnetic nanoparticles. Preprints 2019, 2019010046. https://doi.org/10.20944/preprints201901.0046.v1
Mierzwa, M.; Krysinski, P.; Bilewicz, R. Hybrid delivery systems for methotrexate-lipidic liquid crystalline cubic phases and cubosomes with magnetic nanoparticles. Preprints2019, 2019010046. https://doi.org/10.20944/preprints201901.0046.v1
APA Style
Mierzwa, M., Krysinski, P., & Bilewicz, R. (2019). Hybrid delivery systems for methotrexate-lipidic liquid crystalline cubic phases and cubosomes with magnetic nanoparticles. Preprints. https://doi.org/10.20944/preprints201901.0046.v1
Chicago/Turabian Style
Mierzwa, M., Pawel Krysinski and Renata Bilewicz. 2019 "Hybrid delivery systems for methotrexate-lipidic liquid crystalline cubic phases and cubosomes with magnetic nanoparticles" Preprints. https://doi.org/10.20944/preprints201901.0046.v1
Abstract
The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are considered a prospective hybrid drug delivery system. Commonly, cubosomes or liposomes are employed, but not in the case of toxic methotrexate, known to block receptors responsible for folate transport into the cells. The release profiles of the drug from the lipidic films were monitored electrochemically and described using the Higuchi model. They were also modified via changes in temperature; the release was faster, although deviating from the model when the temperature was increased. Magnetocubosomes - cubic phase nanoparticles containing hydrophobic magnetic nanoparticles placed in an alternating magnetic field of low frequency and amplitude, stimulated drug release from the suspension, which was monitored spectroscopically. These new biocompatible hybrid materials are very promising, allowing to control the release of the drug at the appropriate sites, but do require further investigations into their in vitro cytotoxicity and in vivo biodistribution.
Keywords
Keywords: methotrexate, cubic phase, magnetocubosomes, monoolein, liquid crystalline phase, drug delivery system, alternating magnetic field
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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