Preprint Article Version 1 This version is not peer-reviewed

Cytotoxicity of Biogenic Gold Nanoparticles against Lung Cancer Cell Line (A549): An Application Oriented Perspective

Version 1 : Received: 24 December 2018 / Approved: 25 December 2018 / Online: 25 December 2018 (14:05:09 CET)

How to cite: Jha, B.; Prasad, K.; Jha, A.K. Cytotoxicity of Biogenic Gold Nanoparticles against Lung Cancer Cell Line (A549): An Application Oriented Perspective. Preprints 2018, 2018120308 (doi: 10.20944/preprints201812.0308.v1). Jha, B.; Prasad, K.; Jha, A.K. Cytotoxicity of Biogenic Gold Nanoparticles against Lung Cancer Cell Line (A549): An Application Oriented Perspective. Preprints 2018, 2018120308 (doi: 10.20944/preprints201812.0308.v1).

Abstract

The present work encompasses an application-oriented perspective to the possible employment of gold nanoparticles as nanomedicine in cancer therapeutics. The rationale of the work lies in the growing needs for assessment of advanced alternative treatment of cancer employing functionalized nanoparticles as nanomedicine. Gold nanoparticles fabricated via green chemistry methods by leaves of a time-honored medicinal plant, Piper betle were ascertained for their synthesis and properties under the umbrella of characterization of nanoparticles, through various techniques like UV-vis spectroscopy, FTIR spectroscopy, X-ray diffraction, and scanning electron microscopy. The cytotoxicity assay of well-characterized gold nanoparticles was monitored against lung cancer cell line (A549) by metabolic and imaging assays. MTT assay or the metabolic assay was performed for a range of nanoparticles’ concentrations. The results were promising and proved to be a leading-edge venture, envisaging the possibility of gold nanoparticles for cancer therapeutics.

Subject Areas

gold nanoparticles; green chemistry; Piper betle; Lung cancer cell line (A549); nanomedicine

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