Version 1
: Received: 15 November 2018 / Approved: 16 November 2018 / Online: 16 November 2018 (11:34:24 CET)
How to cite:
Banerjee, N.; Panda, S.; Chatterjee, S. G-Quadruplex targeting ligands: A hope and a new horizon in Cancer Therapeutics. Preprints2018, 2018110409. https://doi.org/10.20944/preprints201811.0409.v1
Banerjee, N.; Panda, S.; Chatterjee, S. G-Quadruplex targeting ligands: A hope and a new horizon in Cancer Therapeutics. Preprints 2018, 2018110409. https://doi.org/10.20944/preprints201811.0409.v1
Banerjee, N.; Panda, S.; Chatterjee, S. G-Quadruplex targeting ligands: A hope and a new horizon in Cancer Therapeutics. Preprints2018, 2018110409. https://doi.org/10.20944/preprints201811.0409.v1
APA Style
Banerjee, N., Panda, S., & Chatterjee, S. (2018). G-Quadruplex targeting ligands: A hope and a new horizon in Cancer Therapeutics. Preprints. https://doi.org/10.20944/preprints201811.0409.v1
Chicago/Turabian Style
Banerjee, N., Suman Panda and Subhrangsu Chatterjee. 2018 "G-Quadruplex targeting ligands: A hope and a new horizon in Cancer Therapeutics" Preprints. https://doi.org/10.20944/preprints201811.0409.v1
Abstract
G-quadruplex, a unique secondary structure in nucleic acids found throughout human genome elicited widespread interest in the field of therapeutic research. Being present in key regulatory regions of oncogenes, G-quadruplex structure regulates transcription, translation, splicing, telomere stability etc. Changes in its structure and stability lead to differential expression of oncogenes causing cancer. Thus, targeting G-Quadruplex structures with small molecules/ other biologics has shown elevated research interest. Covering previous reports, in this review we try to enlighten the facts on the structural diversity in G-quadruplex ligands aiming to provide newer insights to design first-in-class drugs for the next generation cancer treatment.
Keywords
G quadruplex, Oncogene, ligand, cancer
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
