G-Quadruplex targeting ligands: A hope and a new horizon in Cancer Therapeutics

Nilanjan Banerjee; Suman Panda; Subhrangsu Chatterjee

doi:10.20944/preprints201811.0409.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 15 November 2018 / Approved: 16 November 2018 / Online: 16 November 2018 (11:34:24 CET)

G-quadruplex, a unique secondary structure in nucleic acids found throughout human genome elicited widespread interest in the field of therapeutic research. Being present in key regulatory regions of oncogenes, G-quadruplex structure regulates transcription, translation, splicing, telomere stability etc. Changes in its structure and stability lead to differential expression of oncogenes causing cancer. Thus, targeting G-Quadruplex structures with small molecules/ other biologics has shown elevated research interest. Covering previous reports, in this review we try to enlighten the facts on the structural diversity in G-quadruplex ligands aiming to provide newer insights to design first-in-class drugs for the next generation cancer treatment.

G quadruplex, Oncogene, ligand, cancer

CHEMISTRY, Medicinal Chemistry

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G-Quadruplex targeting ligands: A hope and a new horizon in Cancer Therapeutics

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