Preprint Article Version 1 This version is not peer-reviewed

Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Version 1 : Received: 17 October 2018 / Approved: 17 October 2018 / Online: 17 October 2018 (09:34:06 CEST)

A peer-reviewed article of this Preprint also exists.

Gonçalves, I.L.; Porto Kagami, L.; Machado das Neves, G.; Rockenbach, L.; Davi, L.; Soares, A.F.; Garcia, S.C.; Eifler-Lima, V.L. Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate. Molbank 2018, 2018, M1029. Gonçalves, I.L.; Porto Kagami, L.; Machado das Neves, G.; Rockenbach, L.; Davi, L.; Soares, A.F.; Garcia, S.C.; Eifler-Lima, V.L. Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate. Molbank 2018, 2018, M1029.

Journal reference: Molbank 2018, 2018, M1029
DOI: 10.3390/M1029

Abstract

The Biginelli reaction is a highly versatile reaction, which leads to dihydropyrimidinones/thiones. This scaffold is reported as being a privileged structure due to its ability to interact with biological targets. Synthesis of ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate was achieved through the Biginelli reaction using a functionalized thiourea. In silico studies demonstrated that the compound title showed good potential for interacting with ecto-5’-nucleotidase, which has been considered as a target in designs for anti-cancer drugs.

Subject Areas

Biginelli reaction; dihydropyrimidin-2-thiones; synthesis, virtual screening, drug design; LaSOM 282

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