Design, Synthesis and Photophysical Studies of Improved Xanthene Dye to Detect Acetate

Jose Manuel Paredes; Delia Miguel; Sandra Resa; Maria del Carmen Gonzalez-Garcia; Yanira Diaz-Torres; Juan Manuel Cuerva; Luis Crovetto

doi:10.20944/preprints201810.0190.v1

How to cite: Paredes, J.M.; Miguel, D.; Resa, S.; Gonzalez-Garcia, M.D.C.; Diaz-Torres, Y.; Cuerva, J.M.; Crovetto, L. Design, Synthesis and Photophysical Studies of Improved Xanthene Dye to Detect Acetate. Preprints 2018, 2018100190 (doi: 10.20944/preprints201810.0190.v1). Paredes, J.M.; Miguel, D.; Resa, S.; Gonzalez-Garcia, M.D.C.; Diaz-Torres, Y.; Cuerva, J.M.; Crovetto, L. Design, Synthesis and Photophysical Studies of Improved Xanthene Dye to Detect Acetate. Preprints 2018, 2018100190 (doi: 10.20944/preprints201810.0190.v1).

Abstract

Development of biomarkers of analytes with interest in clinic is an important field of study. In this work, we synthesized and analyzed the new fluorescent acetate-biomarker, Iso-PG. The mechanism of detection is the acetate buffer mediated proton transfer reaction. The rate constants involved were obtained, and we measured the change in the fluorescence lifetime produced as a consequence of the presence of acetate in the medium. Finally, we checked its potential use as acetate biomarker in synthetic serum

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Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Design, Synthesis and Photophysical Studies of Improved Xanthene Dye to Detect Acetate

Abstract

Subject Areas

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