Preprint Article Version 1 This version is not peer-reviewed

Design, Synthesis and Photophysical Studies of Improved Xanthene Dye to Detect Acetate

Version 1 : Received: 9 October 2018 / Approved: 9 October 2018 / Online: 9 October 2018 (15:39:16 CEST)

How to cite: Paredes, J.M.; Miguel, D.; Resa, S.; Gonzalez-Garcia, M.D.C.; Diaz-Torres, Y.; Cuerva, J.M.; Crovetto, L. Design, Synthesis and Photophysical Studies of Improved Xanthene Dye to Detect Acetate. Preprints 2018, 2018100190 (doi: 10.20944/preprints201810.0190.v1). Paredes, J.M.; Miguel, D.; Resa, S.; Gonzalez-Garcia, M.D.C.; Diaz-Torres, Y.; Cuerva, J.M.; Crovetto, L. Design, Synthesis and Photophysical Studies of Improved Xanthene Dye to Detect Acetate. Preprints 2018, 2018100190 (doi: 10.20944/preprints201810.0190.v1).

Abstract

Development of biomarkers of analytes with interest in clinic is an important field of study. In this work, we synthesized and analyzed the new fluorescent acetate-biomarker, Iso-PG. The mechanism of detection is the acetate buffer mediated proton transfer reaction. The rate constants involved were obtained, and we measured the change in the fluorescence lifetime produced as a consequence of the presence of acetate in the medium. Finally, we checked its potential use as acetate biomarker in synthetic serum

Subject Areas

Biomarkers, Dye , Fluorescence, acetate detection, FLIM

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