Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

An analysis on Dual Diagnosis Revealed a Possible deviation of Schizophrenia Polygenic Risk Score by Mexican Amerindian Ancestry

Jose Jaime Martínez-Magaña
ORCID logo ,
Thelma Beatriz Gonzalez-Castro
ORCID logo ,
Alma Delia Genis-Mendoza
,
Carlos Alfonso Tovilla-Zarate
ORCID logo ,
Isela Juarez-Rojop
,
Erasmo Saucedo-Uribe
,
Nuria Lanzagorta
ORCID logo ,
Michael Escamilla
,
Luis Macías-Kauffer
,
Humberto Nicolini
*
Version 1 : Received: 11 September 2018 / Approved: 12 September 2018 / Online: 12 September 2018 (01:20:54 CEST)

How to cite: Martínez-Magaña, J.J.; Gonzalez-Castro, T.B.; Genis-Mendoza, A.D.; Tovilla-Zarate, C.A.; Juarez-Rojop, I.; Saucedo-Uribe, E.; Lanzagorta, N.; Escamilla, M.; Macías-Kauffer, L.; Nicolini, H. An analysis on Dual Diagnosis Revealed a Possible deviation of Schizophrenia Polygenic Risk Score by Mexican Amerindian Ancestry. Preprints 2018, 2018090206. https://doi.org/10.20944/preprints201809.0206.v1 Martínez-Magaña, J.J.; Gonzalez-Castro, T.B.; Genis-Mendoza, A.D.; Tovilla-Zarate, C.A.; Juarez-Rojop, I.; Saucedo-Uribe, E.; Lanzagorta, N.; Escamilla, M.; Macías-Kauffer, L.; Nicolini, H. An analysis on Dual Diagnosis Revealed a Possible deviation of Schizophrenia Polygenic Risk Score by Mexican Amerindian Ancestry. Preprints 2018, 2018090206. https://doi.org/10.20944/preprints201809.0206.v1

Abstract

In order to summarized the polygenic background of psychiatric diseases, polygenic risk scores (PRS) have been developed. Recently, PRS have been use to predict patients with higher comorbidities in psychiatric diseases, like dual diagnosis. PRS are principally derived in analysis of Caucasian and Asian populations, we are not aware of how this PRS could be applied in populations with high admixture. In order to explored this, the present work has the aim to analyzed if previous calculated PRS for psychiatric diseases could predict dual diagnosis in Mexican population, and also, if PRS calculation could be influenced by Mexican Amerindian (MA) global ancestry. We performed PRS calculation, using PRSice, with summary genome-wide association statistics previously published for psychiatric diseases, and also, performed Nagelkerke correlation test in order to established if PRS are correlated with dual diagnosis. We found that dual diagnosis could be predicted by major depressive disorder polygenic risk score. Nevertheless, schizophrenia polygenic risk score is highly correlated with global MA ancestry, independently of the schizophrenia diagnosis. Our results reinforced the notion that PRS calculation could be deviated by the MA global ancestry, nevertheless analysis on larger sample sizes are required in order to clarified this issue.

Keywords

Mexican Amerindian, Dual diagnosis, polygenic risk scores, psychiatric diseases, bipolar disorder, schizophrenia, substance use disorder

Subject

Medicine and Pharmacology, Psychiatry and Mental Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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