Preprint Article Version 1 This version is not peer-reviewed

The Relationship between Carotid Intima-Media Thickness and Serum Secreted Frizzled-Related Protein-4 and Dipeptidyl Peptidase-4 in the Diabetic Patients with Cardiovascular Diseases

Version 1 : Received: 28 August 2018 / Approved: 29 August 2018 / Online: 29 August 2018 (09:38:37 CEST)

How to cite: Senyigit, A.; Uzun, H.; Gultepe, I.; Konukoglu, D. The Relationship between Carotid Intima-Media Thickness and Serum Secreted Frizzled-Related Protein-4 and Dipeptidyl Peptidase-4 in the Diabetic Patients with Cardiovascular Diseases. Preprints 2018, 2018080491 (doi: 10.20944/preprints201808.0491.v1). Senyigit, A.; Uzun, H.; Gultepe, I.; Konukoglu, D. The Relationship between Carotid Intima-Media Thickness and Serum Secreted Frizzled-Related Protein-4 and Dipeptidyl Peptidase-4 in the Diabetic Patients with Cardiovascular Diseases. Preprints 2018, 2018080491 (doi: 10.20944/preprints201808.0491.v1).

Abstract

Objective: Diabetes is associated with increased cardiovascular and cerebrovascular disease-related mortality. We investigated the association between carotid intima-media thickness (CIMT) with clusterin (CLU), amylin, secreted frizzled-related protein-4 (SFRP-4), total and active glucagon-like peptide-1 (GLP-1) levels, and dipeptidyl peptidase-4 (DPP-4) in type 2 diabetes mellitus (T2DM) individuals with or without coronary artery disease (CAD). Methods: This study consisted of four groups in Medicine Hospital between April- October, 2017: Control group (mean ages: 50.3 ± 10.7 years, 20 females and 15 males), diabetic group (DM) (mean ages: 53.9 ± 11.1, 14 females and 23 males), CAD group (mean ages: 62.6 ± 11.8, 17 females and 17 males) and CAD+ DM group: (mean ages: 62.6 ± 11.8 years, 18 females and 18 males). Results: Both CAD and CAD+DM groups have higher CIMT levels than controls. CAD+DM group have also significantly higher CIMT levels than DM group. Left external carotid artery (ECA) was only found different in DM group from controls. When compared with controls, DM, CAD groups have low DPP-4 and GLP-1total concentration. Control group have significantly lower SFRP-4 levels than DM, CAD and CAD+DM (p<0.001) groups. Serum GLP-1total levels were found to be significantly low in CAD+DM group when compared to control group. Conclusion: DPP-4 and SFRP-4 levels are predictive marker for atherosclerosis in diabetes, correlates well with HOMA-IR particularly in diabetes. CIMT has the potential to be a clinically useful predictor of vascular risk in diabetic patients with CAD. Large cohorts and at-risk populations are needed to confirm the predictive value of these findings.

Subject Areas

type 2 diabetes mellitus; carotid intima-media thickness; glucagon-like peptide-1; dipeptidyl peptidase-4; clusterin; amylin; secreted Frizzled-related protein-4

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