Preprint Article Version 1 This version is not peer-reviewed

Novel Hybrid Chitosan Derivatives and Chalcones Moiety for Some Biological Applications: Synthesis, Characterization, Antimicrobial and Anti Cancer Activity

Version 1 : Received: 29 July 2018 / Approved: 1 August 2018 / Online: 1 August 2018 (09:38:35 CEST)

How to cite: Bagyaraj, E.; Vakees, E.; Aboobucker Sithique, M. Novel Hybrid Chitosan Derivatives and Chalcones Moiety for Some Biological Applications: Synthesis, Characterization, Antimicrobial and Anti Cancer Activity. Preprints 2018, 2018080011 (doi: 10.20944/preprints201808.0011.v1). Bagyaraj, E.; Vakees, E.; Aboobucker Sithique, M. Novel Hybrid Chitosan Derivatives and Chalcones Moiety for Some Biological Applications: Synthesis, Characterization, Antimicrobial and Anti Cancer Activity. Preprints 2018, 2018080011 (doi: 10.20944/preprints201808.0011.v1).

Abstract

Versatile hybrid organic polymers are prepared using two active intermediates such as cynuric chloride and chitosan derivatives. The prepared chalcones are characterized by using FT-IR, UV, and proton NMR, thermal analysis and Minimum inhibitory Concentration. Thermal stability of the synthesized hybrid polymer is found using TGA and the hybrid chitosan derivative chalcone is thermally stable up to 270 °C. The antimicrobial activity of the prepared chitosan containing chalcone moiety are find out using Minimum Inhibitory Concentration (MIC) method. The synthesized versatile chalcone shows excellent antimicrobial activity against gram-negative bacteria such as Pseudomonas aeruginosa; and Gram-positive bacteria Chalcone containing halogen moiety shows high activity (MIC 7.8 µg/mL) than the hydroxyl containing chalcone. Cytotoxicity activity of the synthesized composites shows high activity.

Subject Areas

chitosan; aldehydes; chalcone; MIC; anti-cancer activity

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