Version 1
: Received: 19 July 2018 / Approved: 19 July 2018 / Online: 19 July 2018 (11:58:22 CEST)
How to cite:
Yang, C.; Zhang, Y.; Zi, Q.; Lin, J.; Yan, S. Uncatalyzed Addition and Cyclization of TSN3 to 1,1-Enediamines: An Effective Green Route to Highly Functionalized 1,2,3-Triazole Compounds. Preprints2018, 2018070354. https://doi.org/10.20944/preprints201807.0354.v1
Yang, C.; Zhang, Y.; Zi, Q.; Lin, J.; Yan, S. Uncatalyzed Addition and Cyclization of TSN3 to 1,1-Enediamines: An Effective Green Route to Highly Functionalized 1,2,3-Triazole Compounds. Preprints 2018, 2018070354. https://doi.org/10.20944/preprints201807.0354.v1
Yang, C.; Zhang, Y.; Zi, Q.; Lin, J.; Yan, S. Uncatalyzed Addition and Cyclization of TSN3 to 1,1-Enediamines: An Effective Green Route to Highly Functionalized 1,2,3-Triazole Compounds. Preprints2018, 2018070354. https://doi.org/10.20944/preprints201807.0354.v1
APA Style
Yang, C., Zhang, Y., Zi, Q., Lin, J., & Yan, S. (2018). Uncatalyzed Addition and Cyclization of T<sub>S</sub>N<sub>3 </sub>to 1,1-Enediamines: An Effective Green Route to Highly Functionalized 1,2,3-Triazole Compounds. Preprints. https://doi.org/10.20944/preprints201807.0354.v1
Chicago/Turabian Style
Yang, C., Jun Lin and Sheng-Jiao Yan. 2018 "Uncatalyzed Addition and Cyclization of T<sub>S</sub>N<sub>3 </sub>to 1,1-Enediamines: An Effective Green Route to Highly Functionalized 1,2,3-Triazole Compounds" Preprints. https://doi.org/10.20944/preprints201807.0354.v1
Abstract
Novel 1,2,3-triazole compounds 3–4 were synthesised via the regioselective addition and cyclization reaction of 1,1-enediamines (EDAMs) 1 with p-methylbenzenesulfonyl azide (TsN3) 2 in 1,4-dioxane at refluxing for 5 hours. As a result, 1,2,3-triazoles 3–4 can be easily and efficiently obtained via catalyst-free click chemistry. The reactions have some advantages such as metal-free catalyst, excellent yield, inexpensive raw materials, and convenient final treatment.
Keywords
1,2,3-triazole; 1,1-enediamines; addition and cyclization; click chemistry
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
