Preprint Article Version 1 This version is not peer-reviewed

Uncatalyzed Addition and Cyclization of TSN3 to 1,1-Enediamines: An Effective Green Route to Highly Functionalized 1,2,3-Triazole Compounds

Version 1 : Received: 19 July 2018 / Approved: 19 July 2018 / Online: 19 July 2018 (11:58:22 CEST)

How to cite: Yang, C.; Zhang, Y.; Zi, Q.; Lin, J.; Yan, S. Uncatalyzed Addition and Cyclization of TSN3 to 1,1-Enediamines: An Effective Green Route to Highly Functionalized 1,2,3-Triazole Compounds. Preprints 2018, 2018070354 (doi: 10.20944/preprints201807.0354.v1). Yang, C.; Zhang, Y.; Zi, Q.; Lin, J.; Yan, S. Uncatalyzed Addition and Cyclization of TSN3 to 1,1-Enediamines: An Effective Green Route to Highly Functionalized 1,2,3-Triazole Compounds. Preprints 2018, 2018070354 (doi: 10.20944/preprints201807.0354.v1).

Abstract

Novel 1,2,3-triazole compounds 3–4 were synthesised via the regioselective addition and cyclization reaction of 1,1-enediamines (EDAMs) 1 with p-methylbenzenesulfonyl azide (TsN3) 2 in 1,4-dioxane at refluxing for 5 hours. As a result, 1,2,3-triazoles 3–4 can be easily and efficiently obtained via catalyst-free click chemistry. The reactions have some advantages such as metal-free catalyst, excellent yield, inexpensive raw materials, and convenient final treatment.

Subject Areas

1,2,3-triazole; 1,1-enediamines; addition and cyclization; click chemistry

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