Preprint Article Version 1 This version is not peer-reviewed

Evaluation of N-arylhydrazone derivatives of orotic acid as stimulators of human mesenchymal stem cell (hMSCs) differentiation.

Version 1 : Received: 13 July 2018 / Approved: 16 July 2018 / Online: 16 July 2018 (09:06:33 CEST)

How to cite: Ali Syed, S.; Bari, A.; Mahmood, A.; Abuelreich, S.; C. Hosten, E.; Betz, R.; M. AlObaid, A.; AlGhadeer, A. Evaluation of N-arylhydrazone derivatives of orotic acid as stimulators of human mesenchymal stem cell (hMSCs) differentiation.. Preprints 2018, 2018070264 (doi: 10.20944/preprints201807.0264.v1). Ali Syed, S.; Bari, A.; Mahmood, A.; Abuelreich, S.; C. Hosten, E.; Betz, R.; M. AlObaid, A.; AlGhadeer, A. Evaluation of N-arylhydrazone derivatives of orotic acid as stimulators of human mesenchymal stem cell (hMSCs) differentiation.. Preprints 2018, 2018070264 (doi: 10.20944/preprints201807.0264.v1).

Abstract

Human mesenchymal stem cells (hMSCs) constitute of cells having potential of self-renewal and proliferation and are commonly isolated from bone marrow aspirates of large bones. The osteogenic potential of these stem cells has been extensively exploited by scientists during the last many years for the biological evaluation of synthetic scaffolds with applications in tissue engineering. Current work aimed to synthesize N-arylhydrazone derivatives of orotic acid and their evaluation as stimulators of human mesenchymal stem cells. Some of the analogs show good to moderate proliferation rate.

Subject Areas

Orotic hydrazide, Arylhydrazone, Mesenchymal Stem Cells, Proliferation

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