Preprint Article Version 1 This version is not peer-reviewed

Optimizing the Role of Polymer Blend in the Preparation of Acyclovir Controlled-Release Tablets: An Approach for Better Patient Compliance

Version 1 : Received: 9 July 2018 / Approved: 10 July 2018 / Online: 10 July 2018 (10:15:00 CEST)

How to cite: Khan, B.; Haider, F.; Shah, K.; Uzair, B.; Hou, K.; Waqas, M.; Rasul, A. Optimizing the Role of Polymer Blend in the Preparation of Acyclovir Controlled-Release Tablets: An Approach for Better Patient Compliance. Preprints 2018, 2018070165 (doi: 10.20944/preprints201807.0165.v1). Khan, B.; Haider, F.; Shah, K.; Uzair, B.; Hou, K.; Waqas, M.; Rasul, A. Optimizing the Role of Polymer Blend in the Preparation of Acyclovir Controlled-Release Tablets: An Approach for Better Patient Compliance. Preprints 2018, 2018070165 (doi: 10.20944/preprints201807.0165.v1).

Abstract

This study was carried out to formulate and evaluate controlled release (CR) matrix tablets of Acyclovir using combination of hydrophilic and hydrophobic polymers. Acyclovir is a guanine derivative and is its half-life is short hence administered five times a day using immediate release tablets. Six formulations (F1-F6) were developed using Ethocel and Carbopol in equal combinations at drug-polymer (D:P) ratio of 10:5, 10:6, 10:7, 10:8, 10:9 and 10:10. Solubility study was performed using six different solvents. The compatibility studies were carried out using FTIR and DSC. According to USP, Quality Control and dimensional tests (hardness, friability, disintegration and thickness) were executed. In-vitro drug release studies of Acyclovir was carried out in dissolution apparatus using using 0.1 N HCl medium at constant temperature of 37 ± 0.5 ºC. In order to analyze the drug release kinetics, five different mathematical models were applied to the release data. The results showed that there was no incompatibility between drug and polymers. Physical QC tests were found within limits of USP. The release was retarded upto 24 hrs and non-fickian in-vitro drug release mechanism was found. A formulation developed using blend of polymers, showed excellent retention and desired release profiles thus providing absolute control for 24 hrs.

Subject Areas

Acyclovir;Carbapol; Ethocel

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