Preprint Review Version 1 This version is not peer-reviewed

Anomeric Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs

Version 1 : Received: 25 June 2018 / Approved: 25 June 2018 / Online: 25 June 2018 (15:08:22 CEST)

How to cite: Gervay-Hague, J.; Park, S.S.; Hsieh, H. Anomeric Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. Preprints 2018, 2018060395 (doi: 10.20944/preprints201806.0395.v1). Gervay-Hague, J.; Park, S.S.; Hsieh, H. Anomeric Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. Preprints 2018, 2018060395 (doi: 10.20944/preprints201806.0395.v1).

Abstract

Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge. With advances in chemical and enzymatic carbohydrate synthesis, the availability of complex carbohydrates is increasing and developing methods for stereoselective conjugation these polar head groups to proteins and lipids is critically important for pharmaceutical applications. The aim of this review is to provide an overview of commonly employed strategies for installing a functionalized linker at the anomeric position as well as examples of further transformations that have successfully led to glycoconjugation to vaccine constructs for biological evaluation as carbohydrate-based therapeutics.

Subject Areas

Carbohydrates; glycosylation; glycosides; glycoconjugates; anomeric functionalization

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