Preprint Review Version 1 This version is not peer-reviewed

Anomeric Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs

Version 1 : Received: 25 June 2018 / Approved: 25 June 2018 / Online: 25 June 2018 (15:08:22 CEST)

A peer-reviewed article of this Preprint also exists.

Park, S.S.; Hsieh, H.-W.; Gervay-Hague, J. Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. Molecules 2018, 23, 1742. Park, S.S.; Hsieh, H.-W.; Gervay-Hague, J. Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. Molecules 2018, 23, 1742.

Journal reference: Molecules 2018, 23, 1742
DOI: 10.3390/molecules23071742

Abstract

Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge. With advances in chemical and enzymatic carbohydrate synthesis, the availability of complex carbohydrates is increasing and developing methods for stereoselective conjugation these polar head groups to proteins and lipids is critically important for pharmaceutical applications. The aim of this review is to provide an overview of commonly employed strategies for installing a functionalized linker at the anomeric position as well as examples of further transformations that have successfully led to glycoconjugation to vaccine constructs for biological evaluation as carbohydrate-based therapeutics.

Subject Areas

Carbohydrates; glycosylation; glycosides; glycoconjugates; anomeric functionalization

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Rate this article
Views 0
Downloads 0
Comments 0
Metrics 0
Leave a public comment

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.