Preprint Review Version 1 This version is not peer-reviewed

Retinoid X Receptor Antagonists

Version 1 : Received: 12 June 2018 / Approved: 13 June 2018 / Online: 13 June 2018 (10:45:58 CEST)

How to cite: Watanabe, M.; Kakuta, H. Retinoid X Receptor Antagonists. Preprints 2018, 2018060208 (doi: 10.20944/preprints201806.0208.v1). Watanabe, M.; Kakuta, H. Retinoid X Receptor Antagonists. Preprints 2018, 2018060208 (doi: 10.20944/preprints201806.0208.v1).

Abstract

Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but also are candidate drugs for treatment of various diseases, including diabetes and allergy, although no RXR antagonist has yet been approved for clinical use. In this review, we describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research.

Subject Areas

Retinoid X receptor; RXR; antagonists; structural classification; heterodimers; permissive; tRXR

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