Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Recent Advances in Photo-Responsive Polypeptide Derived Nano-Assemblies

Version 1 : Received: 25 May 2018 / Approved: 30 May 2018 / Online: 30 May 2018 (04:52:30 CEST)

A peer-reviewed article of this Preprint also exists.

Yang, L.; Tang, H.; Sun, H. Progress in Photo-Responsive Polypeptide Derived Nano-Assemblies. Micromachines 2018, 9, 296. Yang, L.; Tang, H.; Sun, H. Progress in Photo-Responsive Polypeptide Derived Nano-Assemblies. Micromachines 2018, 9, 296.


Stimuli-responsive polymeric materials have attracted significant attentions in a variety of high-value-added and industrial applications during the past decade. Among various stimuli, light is of particular interest as a stimulus due to its unique advantages such as precisely spatiotemporal control, mild conditions, ease of use, and tunability. In recent years, a lot of effort toward synthesis of biocompatible and biodegradable polypeptide has resulted in many examples of photo-responsive nanoparticles. Depending on the specific photochemistry, those polypeptide derived nano-assemblies are capable of crosslinking, disassembling, or morphing into other shapes upon light irradiation. In this mini-review, we aim to assess the current state of photo-responsive polypeptide based nanomaterials. First, those “smart” nanomaterials will be categorized by their photo-triggered events (i.e., crosslinking, degradation, and isomerization) which are inherently governed by photo-sensitive functionalities including o-nitrobenzyl, coumarin, azobenzene, cinnamyl, and spiropyran. In addition, the properties and applications of those polypeptide nanomaterials will be highlighted as well. Finally, the current challenges and future directions of this subject will be evaluated.


stimuli-responsive polymers; synthetic polypeptide; photo-sensitive; self-assembly; morphological transformation


Chemistry and Materials Science, Organic Chemistry

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