Preprint Article Version 1 This version is not peer-reviewed

Selective Interactions with Various G-Quadruplex DNA Forming Sequences by Berberine and Palmatine Analogues

Version 1 : Received: 12 May 2018 / Approved: 14 May 2018 / Online: 14 May 2018 (11:44:10 CEST)

A peer-reviewed article of this Preprint also exists.

Franceschin, M.; Cianni, L.; Pitorri, M.; Micheli, E.; Cacchione, S.; Frezza, C.; Serafini, M.; Hu, M.-H.; Su, H.; Huang, Z.; Gu, L.; Bianco, A. Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues. Molecules 2018, 23, 1423. Franceschin, M.; Cianni, L.; Pitorri, M.; Micheli, E.; Cacchione, S.; Frezza, C.; Serafini, M.; Hu, M.-H.; Su, H.; Huang, Z.; Gu, L.; Bianco, A. Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues. Molecules 2018, 23, 1423.

Journal reference: Molecules 2018, 23, 1423
DOI: 10.3390/molecules23061423

Abstract

In this article/review, the selective interactions of several berberine and palmatine derivatives with various DNA G-quadruplex structures are reported. These derivatives were constructed starting from two natural compounds, berberine and palamatine, through specific synthetic passages following two different schemes for each of them and using several substituents. The details of these synthesis are also described. Indeed, the study of the interactions of these derivative compounds with various G-quadruplex forming sequences was carried out by means of various structural and biochemical techniques. The results show that the presence of suitable side chains are very useful to improve the interaction of the ligands with G-quadruplex structures. Thus, since G-quadruplex formation is promoted by these compounds, which have never been reported before, these may be tested as potential anticancer drugs.

Subject Areas

G-quadruplex DNA; interactions; berberine and palmatine analogues; chemotherapy; NMR; FRET and MST assays

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