Islas, J.F.; Moreno-Cuevas, J.E. A MicroRNA Perspective on Cardiovascular Development and Diseases: An Update. Int. J. Mol. Sci.2018, 19, 2075.
Islas, J.F.; Moreno-Cuevas, J.E. A MicroRNA Perspective on Cardiovascular Development and Diseases: An Update. Int. J. Mol. Sci. 2018, 19, 2075.
Islas, J.F.; Moreno-Cuevas, J.E. A MicroRNA Perspective on Cardiovascular Development and Diseases: An Update. Int. J. Mol. Sci.2018, 19, 2075.
Islas, J.F.; Moreno-Cuevas, J.E. A MicroRNA Perspective on Cardiovascular Development and Diseases: An Update. Int. J. Mol. Sci. 2018, 19, 2075.
Abstract
Study of micro-RNA regulatory networks (known as miRNA’s or miR’s), during development and in known pathologies have been the basis of study over the past decades. Herein, we recapitulate these findings in order to highlight the best underlying mechanisms found to date. We also seek to elucidate how miRNA dysregulation can be associated with many cardiovascular diseases. Furthermore, we discuss miR regulation mechanism during in early development in vivo and invitro. Since many of the miR’s are precursors to transcriptional regulation, we relate back to their molecular control as we can then look together at the fundamental disease they might be exacerbating by this dysregulation.
Keywords
miRNA; cardiomyocytes; cardiovascular diseases
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
