Review
Version 1
Preserved in Portico This version is not peer-reviewed
What Does the Future Hold for Yellow Fever Virus? (I)
Version 1
: Received: 4 May 2018 / Approved: 7 May 2018 / Online: 7 May 2018 (05:19:50 CEST)
A peer-reviewed article of this Preprint also exists.
Klitting, R.; Gould, E.A.; Paupy, C.; de Lamballerie, X. What Does the Future Hold for Yellow Fever Virus? (I). Genes 2018, 9, 291. Klitting, R.; Gould, E.A.; Paupy, C.; de Lamballerie, X. What Does the Future Hold for Yellow Fever Virus? (I). Genes 2018, 9, 291.
Abstract
The recent resurgence of yellow fever virus (YFV) activity in the tropical regions of Africa and South America has sparked renewed interest in this infamous arboviral disease. YFV had been a human plague for centuries prior to the identification of its urban transmission vector, the Aedes aegypti mosquito species, and the development of an efficient live-attenuated vaccine, the YF-17D strain. The combination of vector-control measures and vaccination campaigns drastically reduced YFV incidence in humans on many occasions, but the virus never ceased to circulate in the forest, through its sylvatic invertebrate vector(s) and vertebrate host(s). Outbreaks recently reported in Central Africa (2015-2016) and Brazil (since late 2016), reached considerable proportions in terms of spatial distribution and total numbers of cases, with multiple exports, including to China. In turn, questions regarding the likeliness of occurrence of large urban YFV outbreaks in the Americas or of a successful import of YFV to Asia are currently resurfacing. This two-part review describes the current state of knowledge and gaps regarding the molecular biology and transmission dynamics of YFV, along with an overview of the tools that can be used to manage the disease at the individual, local and global levels.
Keywords
yellow fever virus; Flavivirus; vector-borne transmission, emergence
Subject
Biology and Life Sciences, Virology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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