Preprint Article Version 1 This version is not peer-reviewed

Mesoscopic Modeling of Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles

Version 1 : Received: 30 April 2018 / Approved: 2 May 2018 / Online: 2 May 2018 (11:07:01 CEST)

A peer-reviewed article of this Preprint also exists.

Terrón-Mejía, K.A.; Martínez-Benavidez, E.; Higuera-Ciapara, I.; Virués, C.; Hernández, J.; Domínguez, Z.; Argüelles-Monal, W.; Goycoolea, F.M.; López-Rendón, R.; Gama Goicochea, A. Mesoscopic Modeling of the Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles. Nanomaterials 2018, 8, 425. Terrón-Mejía, K.A.; Martínez-Benavidez, E.; Higuera-Ciapara, I.; Virués, C.; Hernández, J.; Domínguez, Z.; Argüelles-Monal, W.; Goycoolea, F.M.; López-Rendón, R.; Gama Goicochea, A. Mesoscopic Modeling of the Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles. Nanomaterials 2018, 8, 425.

Journal reference: Nanomaterials 2018, 8, 425
DOI: 10.3390/nano8060425

Abstract

Transport of hydrophobic drugs in the human body exhibits complications due to the low solubility of these compounds. With the purpose of enhancing the bioavailability and biodistribution of such drugs, recent studies have reported the use of amphiphilic molecules, such as phospholipids, for synthesis of nanoparticles or nanocapsules. Given that phospholipids can self–assemble in liposomes or micellar structures, they are ideal candidates to function as vehicles of hydrophobic molecules. In this work, we report mesoscopic simulations of nanoliposomes, constituted by lecithin and coated with a shell of chitosan. The stability of such structure and the efficiency of encapsulation of capsaicin, as well as the internal and superficial distribution of capsaicin and chitosan inside the nanoliposome were analyzed. The characterization of the system was carried out through density maps and the potentials of mean force for the lecithin–capsaicin, lecithin–chitosan and capsaicin–chitosan interactions. The results of these simulations show that chitosan is deposited on the surface of the nanoliposome, as has been reported in some experimental works. It was also observed that a nanoliposome of approximately 18 nm in diameter is stable during the simulation. The deposition behavior was found to be influenced by pattern of N-acetylation of chitosan.

Subject Areas

capsaicin; chitosan; lecithin; dissipative particle dynamics

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