Modulatory Effect of Polyphenolic Compounds from the Mangrove tree Rhizophora mangle L. Improving Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice

Leonardo Mendes de Souza Mesquita; Cíntia Rabelo e Paiva Caria; Paola Souza Santos; Caio Cesar Ruy; Natalia da Silva Lima; Débora Kono Taketa Moreira; Claudia Quintino da Rocha; Daniella Carisa Murador; Veridiana Vera de Rosso; Alessandra Gambero; Wagner Vilegas

doi:10.20944/preprints201804.0100.v1

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preprints.org > medicine and pharmacology > orthopedics and sports medicine > doi: 10.20944/preprints201804.0100.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Modulatory Effect of Polyphenolic Compounds from the Mangrove tree Rhizophora mangle L. Improving Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice

Leonardo Mendes de Souza Mesquita

Cíntia Rabelo e Paiva Caria

Paola Souza Santos

Caio Cesar Ruy

Natalia da Silva Lima

Débora Kono Taketa Moreira

Claudia Quintino da Rocha

^* ,

Daniella Carisa Murador

Veridiana Vera de Rosso

Alessandra Gambero

Wagner Vilegas

Version 1 : Received: 8 April 2018 / Approved: 9 April 2018 / Online: 9 April 2018 (08:28:02 CEST)

How to cite: Mendes de Souza Mesquita, L.; Rabelo e Paiva Caria, C.; Souza Santos, P.; Cesar Ruy, C.; da Silva Lima, N.; Kono Taketa Moreira, D.; Quintino da Rocha, C.; Carisa Murador, D.; Vera de Rosso, V.; Gambero, A.; Vilegas, W. Modulatory Effect of Polyphenolic Compounds from the Mangrove tree Rhizophora mangle L. Improving Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice. Preprints 2018, 2018040100. https://doi.org/10.20944/preprints201804.0100.v1 Mendes de Souza Mesquita, L.; Rabelo e Paiva Caria, C.; Souza Santos, P.; Cesar Ruy, C.; da Silva Lima, N.; Kono Taketa Moreira, D.; Quintino da Rocha, C.; Carisa Murador, D.; Vera de Rosso, V.; Gambero, A.; Vilegas, W. Modulatory Effect of Polyphenolic Compounds from the Mangrove tree Rhizophora mangle L. Improving Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice. Preprints 2018, 2018040100. https://doi.org/10.20944/preprints201804.0100.v1

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MDPI and ACS Style

Mendes de Souza Mesquita, L.; Rabelo e Paiva Caria, C.; Souza Santos, P.; Cesar Ruy, C.; da Silva Lima, N.; Kono Taketa Moreira, D.; Quintino da Rocha, C.; Carisa Murador, D.; Vera de Rosso, V.; Gambero, A.; Vilegas, W. Modulatory Effect of Polyphenolic Compounds from the Mangrove tree Rhizophora mangle L. Improving Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice. Preprints 2018, 2018040100. https://doi.org/10.20944/preprints201804.0100.v1

APA Style

Mendes de Souza Mesquita, L., Rabelo e Paiva Caria, C., Souza Santos, P., Cesar Ruy, C., da Silva Lima, N., Kono Taketa Moreira, D., Quintino da Rocha, C., Carisa Murador, D., Vera de Rosso, V., Gambero, A., & Vilegas, W. (2018). Modulatory Effect of Polyphenolic Compounds from the Mangrove tree <em>Rhizophora mangle </em>L. Improving Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice. Preprints. https://doi.org/10.20944/preprints201804.0100.v1

Chicago/Turabian Style

Mendes de Souza Mesquita, L., Alessandra Gambero and Wagner Vilegas. 2018 "Modulatory Effect of Polyphenolic Compounds from the Mangrove tree <em>Rhizophora mangle </em>L. Improving Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice" Preprints. https://doi.org/10.20944/preprints201804.0100.v1

Abstract

Rhizophora mangle L. is a well-known medicinal plant found in mangroves worldwide used to treatment diabetes. This study evaluated the chemical composition of the acetonic extract from Rhizophora mangle barks (AERM), by HPLC-PDA and FIA-ESI-IT-MS/MS and the effects on high-fat diet induced obesity in mice and its mechanism of action by gene expression of inflammatory markers (Pparg, Ppara, Srebf1, Cd36, Tnf, Ccl2, Lep, Il10, Il6, Fasn, 18s). High-fat diet fed mice during 12 weeks was used as model of obesity and associated alterations. The results were very satisfactory, the extract, rich in polyphenolic compounds, flavonoids and phenolic acids, displayed intense antioxidant activity in vitro (608 µmol Trolox/g), and showed excellent activity against non-alcoholic fatty liver disease (NAFLD) and reverse insulin resistance in a model of diet-induced obesity. We can registered a modulatory effect of AERM in liver PPAR-γ mRNA expression associated to an important inhibition of CD36 mRNA expression suggesting that AERM induces the down regulation of CD36 mRNA via PPAR-gamma inhibition. These results support the traditional knowledge about the use of R. mangle for the treatment of type 2 diabetes and reveal the potential of AERM for the treatment of NAFLD and management of obesity and comorbidities.

Keywords

Cd36; mass spectrometry; NAFLD; anti-lypase activity; anti-amylase activity; insulin resistance

Subject

Medicine and Pharmacology, Orthopedics and Sports Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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