Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting

Fabio Sonvico
* ORCID logo ,
Adryana Rocha Clementino
,
Francesca Buttini
,
Gaia Colombo
,
Silvia Pescina
,
Silvia Stanisçuaski Guterres
,
Adriana Raffin Pohlmann
ORCID logo ,
Sara Nicoli
ORCID logo
Version 1 : Received: 8 February 2018 / Approved: 9 February 2018 / Online: 9 February 2018 (10:37:33 CET)

A peer-reviewed article of this Preprint also exists.

Sonvico, F.; Clementino, A.; Buttini, F.; Colombo, G.; Pescina, S.; Stanisçuaski Guterres, S.; Raffin Pohlmann, A.; Nicoli, S. Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting. Pharmaceutics 2018, 10, 34. Sonvico, F.; Clementino, A.; Buttini, F.; Colombo, G.; Pescina, S.; Stanisçuaski Guterres, S.; Raffin Pohlmann, A.; Nicoli, S. Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting. Pharmaceutics 2018, 10, 34.

Abstract

In the field of nasal delivery, one of the most fascinating applications is the delivery of drugs directly to the central nervous system bypassing the blood brain barrier. This approach would provide a series of benefits, such as dose lowering and direct targeting of potent drugs, ultimately reducing their systemic side effects. Recently, clinical trials have explored the nasal administration of insulin for the treatment of Alzheimer’s disease, with promising results. The use of nanomedicines could provide further options for making nose-to-brain delivery reality. In particular, apart from the selection of devices able to deposit the formulation in the upper part of the nose, surface modification of these nanomedicines appears the key strategy to optimize the delivery of drugs from the nasal cavity to the brain. In this review, nanomedicines delivery approaches based on surface electrostatic charges, mucoadhesive polymers, as well as chemical moieties targeting nasal epithelium, will be discussed and critically evaluated for nose-to-brain delivery.

Keywords

nose to brain delivery; nanoparticles; pharmaceutical nanotechnology; mucoadhesion; mucus penetrating particles; targeting; CNS disorders; neurodegenerative diseases; Alzheimer’s disease; Parkinson’s disease

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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