Version 1
: Received: 1 February 2018 / Approved: 1 February 2018 / Online: 1 February 2018 (17:23:31 CET)
Version 2
: Received: 2 February 2018 / Approved: 2 February 2018 / Online: 2 February 2018 (16:22:41 CET)
Version 3
: Received: 20 February 2018 / Approved: 21 February 2018 / Online: 21 February 2018 (16:00:38 CET)
How to cite:
Perez Quinones, J.; Peniche, H.; Peniche, C. Chitosan Based Self-assembled Nanoparticles in Drug Delivery. Preprints.org2018, 2018020012. https://doi.org/10.20944/preprints201802.0012.v3.
Perez Quinones, J.; Peniche, H.; Peniche, C. Chitosan Based Self-assembled Nanoparticles in Drug Delivery. Preprints.org 2018, 2018020012. https://doi.org/10.20944/preprints201802.0012.v3.
Cite as:
Perez Quinones, J.; Peniche, H.; Peniche, C. Chitosan Based Self-assembled Nanoparticles in Drug Delivery. Preprints.org2018, 2018020012. https://doi.org/10.20944/preprints201802.0012.v3.
Perez Quinones, J.; Peniche, H.; Peniche, C. Chitosan Based Self-assembled Nanoparticles in Drug Delivery. Preprints.org 2018, 2018020012. https://doi.org/10.20944/preprints201802.0012.v3.
Abstract
Chitosan is a cationic polysaccharide usually obtained by alkaline deacetylation of chitin poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive and non-toxic. These excellent biological properties make chitosan a good candidate for a platform in developing drug delivery systems having improved biodistribution, increased specificity and sensitivity, and reduced pharmacological toxicity. In particular, chitosan nanoparticles are found to be appropriate for non-invasive routes of drug administration: oral, nasal, pulmonary and ocular routes. These applications are facilitated by the absorption-enhancing effect of chitosan. Many procedures for obtaining chitosan nanoparticles have been proposed. Particularly, the introduction of hydrophobic moieties into chitosan molecules by grafting to generate a hydrophobic-hydrophilic balance promoting self-assembly is a current and appealing approach. The grafting agent can be a hydrophobic moiety forming micelles that can entrap lipophilic drugs or it can be the drug itself. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions. This paper reviews the main approaches for preparing chitosan nanoparticles by self-assembly through both procedures and illustrates the state of the art of their application in drug delivery.
Keywords
chitosan; self-assembled; polyelectrolyte complex; nanoparticle; drug delivery
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
