Preprint Article Version 1 This version not peer reviewed

Two-Year Outcomes of Ab Interno Trabeculectomy with the Trabectome for Chinese Primary Open Angle Glaucoma: A Retrospective Multicenter Study

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these authors contributed equally to this work.
Version 1 : Received: 11 January 2018 / Approved: 11 January 2018 / Online: 11 January 2018 (04:01:57 CET)

How to cite: Dang, Y.; Wang, X.; Cen, Y.; Hong, Y.; Huang, P.; Loewen, N.; Zhang, C. Two-Year Outcomes of Ab Interno Trabeculectomy with the Trabectome for Chinese Primary Open Angle Glaucoma: A Retrospective Multicenter Study. Preprints 2018, 2018010096 (doi: 10.20944/preprints201801.0096.v1). Dang, Y.; Wang, X.; Cen, Y.; Hong, Y.; Huang, P.; Loewen, N.; Zhang, C. Two-Year Outcomes of Ab Interno Trabeculectomy with the Trabectome for Chinese Primary Open Angle Glaucoma: A Retrospective Multicenter Study. Preprints 2018, 2018010096 (doi: 10.20944/preprints201801.0096.v1).

Abstract

To evaluate the 2-year efficacy and safety of ab interno trabeculectomy with the Trabectome in Chinese primary open-angle glaucoma (POAG) patients. This was a multicenter, retrospective study and included POAG patients with or without visually-significant cataracts. The primary outcome was intraocular pressure (IOP) reduction. Secondary outcomes included reduction of glaucoma medications, surgical complications, and success at 2-years. Success was defined as: 1) IOP < 21 mmHg and at least 20% IOP reduction from baseline after 3 months at any two consecutive visits, and 2) no additional glaucoma surgery required. A total of 42 patients were enrolled; thirteen had a history of failed glaucoma surgery. Twelve patients underwent Trabectome surgery combined with phacoemulsification while the remainder underwent Trabectome surgery alone. Overall, the mean preoperative IOP was 21.4±1.23 mmHg. The Trabectome lowered IOP to 18.5± 0.94 mmHg at 2 years (P<0.05). The number of glaucoma medications also decreased from a baseline of 2.0±0.9 to 1.2± 0.21 at 2 years (P=0.04). The overall success was 78%, with patients undergoing combined surgery having a higher success than those with Trabectome surgery alone (100% vs. 76%). No major complications were seen. The Trabectome appears to be an efficient and safe procedure in Chinese POAG patients in the long-term.

Subject Areas

primary open-angle glaucoma; minimally invasive glaucoma surgery; ab interno trabeculectomy; intraocular pressure; success rate

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