Version 1
: Received: 14 December 2017 / Approved: 15 December 2017 / Online: 15 December 2017 (12:01:47 CET)
Version 2
: Received: 29 December 2017 / Approved: 2 January 2018 / Online: 2 January 2018 (05:21:45 CET)
How to cite:
Haslam, C.; Damiati, S.; Whitley, T.; Davey, P.; Ifeachor, E.; Awan, S.A. Chemical Vapour Deposition Graphene Field-Effect Transistors for Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker. Preprints2017, 2017120106. https://doi.org/10.20944/preprints201712.0106.v2
Haslam, C.; Damiati, S.; Whitley, T.; Davey, P.; Ifeachor, E.; Awan, S.A. Chemical Vapour Deposition Graphene Field-Effect Transistors for Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker. Preprints 2017, 2017120106. https://doi.org/10.20944/preprints201712.0106.v2
Haslam, C.; Damiati, S.; Whitley, T.; Davey, P.; Ifeachor, E.; Awan, S.A. Chemical Vapour Deposition Graphene Field-Effect Transistors for Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker. Preprints2017, 2017120106. https://doi.org/10.20944/preprints201712.0106.v2
APA Style
Haslam, C., Damiati, S., Whitley, T., Davey, P., Ifeachor, E., & Awan, S.A. (2018). Chemical Vapour Deposition Graphene Field-Effect Transistors for Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker. Preprints. https://doi.org/10.20944/preprints201712.0106.v2
Chicago/Turabian Style
Haslam, C., Emmanuel Ifeachor and Shakil A. Awan. 2018 "Chemical Vapour Deposition Graphene Field-Effect Transistors for Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker" Preprints. https://doi.org/10.20944/preprints201712.0106.v2
Abstract
We report on the development of chemical vapour deposition (CVD) based graphene field effect transistor (GFET) immunosensors for the sensitive detection of Human Chorionic Gonadotropin (hCG), a glycoprotein risk biomarker of certain cancers. The GFET sensors were fabricated on Si/SiO2 substrate using photolithography with evaporated chromium and sputtered gold contacts. GFET channels were functionalized with a linker molecule to immobile anti-hCG antibody on the surface of graphene. Binding reaction of the antibody with varying concentration levels of hCG antigen demonstrated the limit of detection of the GFET sensors to be below 1 pg/mL using four-probe electrical measurements. We also show annealing can significantly improve the carrier transport properties of GFETs and shift the Dirac point (Fermi level) with reduced p-doping in back-gated measurements. The developed GFET biosensors are generic and could find applications in a broad range of medical diagnostics in addition to cancer, such as neurodegenerative (Alzheimer’s, Parkinson’s and Lewy body) and cardiovascular disorders.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
