Preprint Review Version 1 This version is not peer-reviewed

DBS in Treatment of Post-Traumatic Stress Disorder

Version 1 : Received: 6 December 2017 / Approved: 8 December 2017 / Online: 8 December 2017 (07:21:28 CET)

A peer-reviewed article of this Preprint also exists.

Lavano, A.; Guzzi, G.; Della Torre, A.; Lavano, S.M.; Tiriolo, R.; Volpentesta, G. DBS in Treatment of Post-Traumatic Stress Disorder. Brain Sci. 2018, 8, 18. Lavano, A.; Guzzi, G.; Della Torre, A.; Lavano, S.M.; Tiriolo, R.; Volpentesta, G. DBS in Treatment of Post-Traumatic Stress Disorder. Brain Sci. 2018, 8, 18.

Journal reference: Brain Sci. 2018, 8, 18
DOI: 10.3390/brainsci8010018

Abstract

Background: Post-traumatic stress disorder (PTSD) is a common debilitating psychiatric condition for which pharmacological therapy is not always solvable. Various treatments have been suggested for these patients. Deep brain stimulation (DBS) is currently under investigation for patients affected by PTSD. 2) Methods: We review the neurocircuitry and up to date clinical concepts that may be of relevance for the implementation of DBS in posttraumatic stress disorder (PTSD). 3) Results: The role of DBS in treatment-refractory PTSD patients has been investigated relying on both preclinical and clinical studies. 4) Conclusions: DBS for PTSD is in its preliminary phases and likely to provide hope to patients with medical refractory PTSD following the results of randomized controlled studies.

Subject Areas

posttraumatic stress disorder; deep brain stimulation; fear extinction; amygdala; prefrontal cortex

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