Submitted:
04 November 2017
Posted:
06 November 2017
You are already at the latest version
Abstract
A new synthetic approach to polyfunctional hexahydropyrrolo[3,4-b]pyrroles was developed based on cyclization of N-arylbromomaleimides with aminocrotonic acid esters. A highly chemo- and stereoselective reaction is a Hantzsch-type domino process, involving the steps of initial nucleophilic C-addition or substitution and subsequent intramolecular nucleophilic addition without recyclyzation of imide cycle.
Keywords:
pyrrole
; pyrrolo[3
; 4-b]pyrrole
; bromomaleimide
; aminocrotonate
; domino reaction
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