Preprint Review Version 1 This version not peer reviewed

Regulation and Sensing of Inflammasomes and Their Impact on Intestinal Health

Version 1 : Received: 24 October 2017 / Approved: 25 October 2017 / Online: 25 October 2017 (02:46:14 CEST)

A peer-reviewed article of this Preprint also exists.

Ranson, N.; Kunde, D.; Eri, R. Regulation and Sensing of Inflammasomes and Their Impact on Intestinal Health. Int. J. Mol. Sci. 2017, 18, 2379. Ranson, N.; Kunde, D.; Eri, R. Regulation and Sensing of Inflammasomes and Their Impact on Intestinal Health. Int. J. Mol. Sci. 2017, 18, 2379.

Journal reference: Int. J. Mol. Sci. 2017, 18, 2379
DOI: 10.3390/ijms18112379

Abstract

Pattern recognition receptors such as nucleotide-binding oligomerization domain (NOD)-containing protein receptors (NLRs) and the pyrin and HIN domain (PYHIN) receptors initiate the inflammatory response following cell stress or pathogenic challenge. When activated some of these receptors oligomerize to form the structural backbone of a signalling platform known as the inflammasome. The inflammasome promotes the activation of caspase-1 and the maturation of the proinflammatory cytokines, interleukin (IL)-1β and IL-18. In the gut dysregulation of the inflammasome complex is thought to be a contributing factor in the development of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD). The importance of inflammasomes to intestinal health has been emphasized by various inflammasome deficient mice in dextran sulphate sodium (DSS) models of intestinal inflammation and by the identification of novel potential candidate genes in population based human studies. In this review we summarise the most recent finding with regard to formation, sensing and regulation of the inflammasome complex and highlight their importance in maintaining intestinal health.

Subject Areas

inflammasomes; ulcerative colitis; Crohn’s disease; interleukin (IL)-1β; IL-18

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Rate this article
Views 0
Downloads 0
Comments 0
Metrics 0
Leave a public comment

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.