Preprint Review Version 1 This version is not peer-reviewed

Microbiome and Probiotics inHealth and HIV Infection

Version 1 : Received: 6 May 2017 / Approved: 8 May 2017 / Online: 8 May 2017 (12:10:17 CEST)

A peer-reviewed article of this Preprint also exists.

D’Angelo, C.; Reale, M.; Costantini, E. Microbiota and Probiotics in Health and HIV Infection. Nutrients 2017, 9, 615. D’Angelo, C.; Reale, M.; Costantini, E. Microbiota and Probiotics in Health and HIV Infection. Nutrients 2017, 9, 615.

Journal reference: Nutrients 2017, 9, 615
DOI: 10.3390/nu9060615

Abstract

Microbiota plays a key role in various body’s functions, physiological, metabolic and immunological processes, through different mechanisms such as the regulation of the development and/or functions of different types of immune cells in the intestines. Several evidences indicate that alteration in the gut microbiota can influence infectious and non-infectious diseases. Bacteria that resides on the mucosal surface or within the mucus layer participate in interactions with the host immune system, and a healthy gut microbiota is essential for the development of mucosal immunity. The immunomodulatory activity of probiotics has been proposed in several bowel disorders or in aging-related dysfunctions. In HIV infected patients, the intestinal immune system is affected and inflammation persists during ART therapy too. Several studies are in progress to investigate the ability of probiotics to modulate epithelial barrier functions, microbiota composition and microbial translocation in HIV infection. This mini-review aims to suggest how the use of probiotics is beneficial not only in maintaining a healthy status but also to improve conditions in HIV subjects.

Subject Areas

microbiome; probiotics, dietary supplements; nutrition; HIV infection, inflammation

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