Preprint Review Version 1 NOT YET PEER-REVIEWED

Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

Version 1 : Received: 15 March 2017 / Approved: 16 March 2017 / Online: 16 March 2017 (09:42:52 CET)

A peer-reviewed article of this Preprint also exists.

Oliveira, A.F.C.S.; Teixeira, R.R.; Oliveira, A.S.; Souza, A.P.M.; Silva, M.L.; Paula, S.O. Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses. Molecules 2017, 22, 505. Oliveira, A.F.C.S.; Teixeira, R.R.; Oliveira, A.S.; Souza, A.P.M.; Silva, M.L.; Paula, S.O. Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses. Molecules 2017, 22, 505.

Journal reference: Molecules 2017, 22, 505
DOI: 10.3390/molecules22030505

Abstract

Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of infection and thousands of deaths worldwide. Therefore, several investigations were conducted over the past few years to find antiviral compounds for the treatment of DENV and CHIKV infections. One attractive strategy is the screening of compounds that target enzymes involved in the replication of both DENV and CHIKV. In this review, we describe advances in the evaluation of natural products targeting the enzymes involved in the replication of these viruses.

Subject Areas

dengue; chikungunya; virus enzymes; antiviral; natural products

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