Shahid, A.; Ahmed, N.S.; Saleh, T.S.; Al-Thabaiti, S.A.; Basahel, S.N.; Schwieger, W.; Mokhtar, M. Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing a Ball Mill Technique: A Green Sustainable Process. Catalysts2017, 7, 84.
Shahid, A.; Ahmed, N.S.; Saleh, T.S.; Al-Thabaiti, S.A.; Basahel, S.N.; Schwieger, W.; Mokhtar, M. Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing a Ball Mill Technique: A Green Sustainable Process. Catalysts 2017, 7, 84.
Shahid, A.; Ahmed, N.S.; Saleh, T.S.; Al-Thabaiti, S.A.; Basahel, S.N.; Schwieger, W.; Mokhtar, M. Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing a Ball Mill Technique: A Green Sustainable Process. Catalysts2017, 7, 84.
Shahid, A.; Ahmed, N.S.; Saleh, T.S.; Al-Thabaiti, S.A.; Basahel, S.N.; Schwieger, W.; Mokhtar, M. Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing a Ball Mill Technique: A Green Sustainable Process. Catalysts 2017, 7, 84.
Abstract
A sustainable green one pot procedure for the synthesis of dihydropyrimidinones (DHPMs) derivatives by a three-component reaction of β-ketoester derivatives, aldehyde and urea or thiourea over the alkali-treated H-ZSM-5 zeolite under ball-milling has been developed. The product was isolated by simple washing of the crude reaction residue with ethyl acetate followed by evaporation of solvent. The hierachical zeolite catalyst (MFI27_6) showed high yield (86–96%) of dihydropyrimidinones (DHPMs), in very short time (10-30 min). The catalyst is recycled for subsequent reactions in four runs without appreciable loss of activity and high yields of products provide efficient protocol for Biginelli reactions.
Chemistry and Materials Science, Applied Chemistry
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