Preprint Article Version 1 NOT YET PEER-REVIEWED

Vitamin-D Deficiency Predicts Infections in Young North Indian Children: A Secondary Data Analysis

Version 1 : Received: 7 November 2016 / Approved: 8 November 2016 / Online: 8 November 2016 (10:40:34 CET)

How to cite: Chowdhury, R.; Taneja, S.; Bhandari, N.; Sinha, B.; Upadhyay, R.; Bhan, M.; Strand, T. Vitamin-D Deficiency Predicts Infections in Young North Indian Children: A Secondary Data Analysis. Preprints 2016, 2016110049 (doi: 10.20944/preprints201611.0049.v1). Chowdhury, R.; Taneja, S.; Bhandari, N.; Sinha, B.; Upadhyay, R.; Bhan, M.; Strand, T. Vitamin-D Deficiency Predicts Infections in Young North Indian Children: A Secondary Data Analysis. Preprints 2016, 2016110049 (doi: 10.20944/preprints201611.0049.v1).

Abstract

Recent studies have demonstrated a relationship between poor vitamin D status and respiratory infections and diarrhea among young children. Acute lower respiratory infections (ALRI) and diarrhea are among the two most important causes of death in under-5 children. In this analysis, we examine the extent to which vitamin-D deficiency (<10 ng/ml) predicts these outcomes using data from a randomized controlled trial (RCT) of daily folic acid and/ or vitamin B12 supplementation for six months in 6 to 30 months old children conducted in Delhi, India. Of the 960 subjects who had vitamin-D concentrations measured, 331(34.5%) were vitamin-D deficient. We found, after controlling for relevant potential confounders (age, sex, breastfeeding status, wasting, stunting, underweight, anemia status at base line and season), the risk of ALRI was significantly higher among vitamin-D deficient (OR 1.26; 95% CI: 1.03 to 1.55) compared to vitamin-D-replete children in the six months follow-up period. Vitamin-D status was not significantly associated with episodes of diarrhea and clinical pneumonia. The extent of causal relationship of vitamin-D status and ALRI needs to be explored in further studies.

Subject Areas

vitamin-D deficiency; ALRI; Indian children

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