PreprintArticleVersion 1This version is not peer-reviewed
A Novel Series of Thiazoles and 1,3,4-Thiadiazoles Bearing Thiazole Moiety as Anticancer Agents: Synthesis, Spectral Studies, Biological Evaluation and Structure Activity relationship
Version 1
: Received: 10 August 2016 / Approved: 11 August 2016 / Online: 11 August 2016 (11:05:21 CEST)
How to cite:
Gomha, S.M.; Kheder, N.A.; Abdelaziz, M.R.; Mabkhot, Y.N. A Novel Series of Thiazoles and 1,3,4-Thiadiazoles Bearing Thiazole Moiety as Anticancer Agents: Synthesis, Spectral Studies, Biological Evaluation and Structure Activity relationship. Preprints2016, 2016080119 (doi: 10.20944/preprints201608.0119.v1).
Gomha, S.M.; Kheder, N.A.; Abdelaziz, M.R.; Mabkhot, Y.N. A Novel Series of Thiazoles and 1,3,4-Thiadiazoles Bearing Thiazole Moiety as Anticancer Agents: Synthesis, Spectral Studies, Biological Evaluation and Structure Activity relationship. Preprints 2016, 2016080119 (doi: 10.20944/preprints201608.0119.v1).
Cite as:
Gomha, S.M.; Kheder, N.A.; Abdelaziz, M.R.; Mabkhot, Y.N. A Novel Series of Thiazoles and 1,3,4-Thiadiazoles Bearing Thiazole Moiety as Anticancer Agents: Synthesis, Spectral Studies, Biological Evaluation and Structure Activity relationship. Preprints2016, 2016080119 (doi: 10.20944/preprints201608.0119.v1).
Gomha, S.M.; Kheder, N.A.; Abdelaziz, M.R.; Mabkhot, Y.N. A Novel Series of Thiazoles and 1,3,4-Thiadiazoles Bearing Thiazole Moiety as Anticancer Agents: Synthesis, Spectral Studies, Biological Evaluation and Structure Activity relationship. Preprints 2016, 2016080119 (doi: 10.20944/preprints201608.0119.v1).
Abstract
A novel series of thiazole based-1,3,4-thiadiazoles were designed and prepared via the reaction of the 2-(4-methyl-2-phenylthiazole-5-carbonyl)-N-phenylhydrazinecarbothioamide with the appropriate hydrazonoyl chlorides. The structures of the newly synthesized compounds were established based on spectroscopic evidences and their alternative syntheses. Thirteen new 1,3,4-thiadiazoles have been evaluated for their anticancer activity against liver carcinoma cell line (HepG2). Also, their structure activity relationship (SAR) was studied. The 1,3,4-thiadiazoles 12d, 12c, 6g,18b, 6c, and 6f(IC50 = 0.82, 0.91, 1.06, 1.25, 1.29 and 1.88 µM, respectively) have promising antitumor activity against liver carcinoma cell line (HepG2).
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sobhi M. Gomha
