In a finite graph, an independent set is a group of vertices that are not connected by edges. The independence, or independent number, tells how big the largest collection of vertices is where no two nodes are next to each other. When optimizing network architecture, error correcting codes, and resource allocation, the independence number a crucial metric in graph theory plays a significant role. In this article we investigate independence within structured graph families, specifically Toeplitz graphs and circulant graphs. For these graphs, solutions are computationally tractable because of periodic structure which makes them indispensable for combinatorial optimization, modeling cyclic communication protocols, and parallel grid based systems. For k = 2,3,4,5, this problem is solved for Cn < 1,k >, in 2008 (ISITAE) [33], but it remains open for bigger families of circulant graphs that are subject to NP-Hard and for Toeplitz graphs. Moreover, this research solve an open problem for Toeplitz and generalized circulant graphs that highlight an in depth study of the independence numbers that fluctuate across a broad spectrum of generating values and their precise bounds.