Submitted:
05 September 2025
Posted:
08 September 2025
You are already at the latest version
Abstract
Keywords:
1. Introduction
2. Methodology
3. Results
4. Discussion
5. Conclusions
Funding
Acknowledgments
Ethics Approval
Conflicts of Interest
Contributions
References
- World Health Organization. Malnutrition [Internet]. Geneva: World Health Organization; [cited 2025 Jan 28]. Available from: https://www.who.int/news-room/fact-sheets/detail/malnutrition.
- Kramer, C.V.; Allen, S. Malnutrition in developing countries. Paediatr Child Health. 2015, 25, 422–427. [Google Scholar] [CrossRef]
- De Onis, M.; Branca, F. Childhood stunting: A global perspective. Matern Child Nutr. 2016, 12 (Suppl 1), 12–26. [Google Scholar] [CrossRef]
- UNICEF, World Health Organization. Levels and trends in child malnutrition: Key findings of the 2019 edition of the Joint Child Malnutrition Estimates. Geneva: World Health Organization; 2020.
- Black, R.E.; Victora, C.G.; Walker, S.P.; Bhutta, Z.A.; Christian, P.; de Onis, M.; et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 2013, 382, 427–451. [Google Scholar] [CrossRef]
- Soliman, A.; De Sanctis, V.; Alaaraj, N.; Ahmed, S.; Alyafei, F.; Hamed, N.; et al. Early and long-term consequences of nutritional stunting: From childhood to adulthood. Acta Biomed. 2021, 92, e2021168. [Google Scholar]
- Leroy, J.L.; Frongillo, E.A. Perspective: What does stunting really mean? A critical review of the evidence. Adv Nutr. 2019, 10, 196–204. [Google Scholar]
- Government of Pakistan, UNICEF. National Nutrition Survey 2018 – Key findings report [Internet]. Islamabad: Ministry of National Health Services, Regulations and Coordination; 2019 [cited 2025 Jan 28]. Available from: https://www.unicef.org/pakistan/media/1951/file/Final%20Key%20Findings%20Report%202019.pdf.
- Soofi, S.B.; Khan, A.; Kureishy, S.; Hussain, I.; Habib, M.A.; Umer, M.; et al. Determinants of stunting among children under five in Pakistan. Preprints.org [Preprint]. 2023 [cited 2025 Jan 28]. Available from: https://doi.org/10.20944/preprints202307.1107.v1.
- Grantham-McGregor, S.; Cheung, Y.B.; Cueto, S.; Glewwe, P.; Richter, L.; Strupp, B. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007, 369, 60–70. [Google Scholar] [CrossRef]
- Hoddinott, J.; Alderman, H.; Behrman, J.R.; Haddad, L.; Horton, S. The economic rationale for investing in stunting reduction. Matern Child Nutr. 2013, 9 (Suppl 2), 69–82. [Google Scholar] [CrossRef]
- Victora, C.G.; Adair, L.; Fall, C.; Hallal, P.C.; Martorell, R.; Richter, L.; et al. Maternal and child undernutrition: Consequences for adult health and human capital. Lancet. 2008, 371, 340–357. [Google Scholar] [CrossRef] [PubMed]
- Government of Pakistan. Pakistan Multi-Sectoral Nutrition Strategy 2018–2025. Islamabad: Ministry of Planning, Development & Reform; 2018.
- Ahmed, T.; Hossain, M.; Mahfuz, M.; Choudhury, N.; Ahmed, S. Imperatives for reducing child stunting in Bangladesh. Matern Child Nutr. 2019, 15 (Suppl 1), e12703. [Google Scholar] [CrossRef] [PubMed]
- English, R.; Peer, N.; Honikman, S.; Tugendhaft, A.; Hofman, K.J. ‘First 1000 days’ health interventions in low- and middle-income countries: Alignment of South African policies with high-quality evidence. Glob Health Action. 2017, 10, 1340396. [Google Scholar] [CrossRef] [PubMed]
- Soofi, S.B.; Khan, G.N.; Ariff, S.; Ihtesham, Y.; Tanimoune, M.; Rizvi, A.; et al. Effectiveness of nutritional supplementation during the first 1000 days of life to reduce child undernutrition: A cluster randomized controlled trial in Pakistan. Lancet Reg Health Southeast Asia. 2022, 4, 100051. [Google Scholar] [CrossRef]
- Bhutta, Z.A.; Das, J.K.; Rizvi, A.; Gaffey, M.F.; Walker, N.; Horton, S.; et al. Evidence-based interventions for improvement of maternal and child nutrition: What can be done and at what cost? Lancet. 2013, 382, 452–477. [Google Scholar] [CrossRef]
- Taneja, S.; Chowdhury, R.; Dhabhai, N.; Upadhyay, R.P.; Mazumder, S.; Sharma, S.; et al. Impact of a package of health, nutrition, psychosocial support, and WaSH interventions delivered during preconception, pregnancy, and early childhood periods on birth outcomes and linear growth at 24 months: Factorial, individually randomized controlled trial. BMJ. 2022, 379, e072486. [Google Scholar]
- Kulwa, K.B.; Verstraeten, R.; Bouckaert, K.P.; Mamiro, P.S.; Kolsteren, P.W.; Lachat, C. Effectiveness of a nutrition education package in improving feeding practices, dietary adequacy and growth of infants and young children in rural Tanzania: Rationale, design and methods of a cluster randomized trial. BMC Public Health. 2014, 14, 1077. [Google Scholar] [CrossRef]
- Aga Khan Development Network. Central Asia Stunting Initiative (CASI) annual report 2022 [Internet]. 2022 [cited 2025 Feb 20]. Available from: https://akdnehrc.com/annual-reports/2022/casi.html.
- Centre for Epidemiology and Evidence. Study design for evaluating population health and health service interventions: A guide. Sydney: NSW Ministry of Health; 2023.
- Cochran, W.G. Sampling techniques. 2nd ed. New York: Wiley; 1963.
- World Health Organization. AnthroPlus for personal computers manual: Software for assessing growth of the world’s children and adolescents [Internet]. Geneva: WHO; 2009 [cited 2025 Jan 28]. Available from: https://www.who.int/tools/growth-reference-data-for-5to19-years/application-tools.
- Sullivan, G.M.; Feinn, R. Using effect size—or why the P value is not enough. J Grad Med Educ. 2012, 4, 279–282. [Google Scholar] [CrossRef]
- Islam, M.R.; Rahman, M.S.; Rahman, M.M.; Nomura, S.; De Silva, A.; Lanerolle, P.; et al. Reducing childhood malnutrition in Bangladesh: The importance of addressing socioeconomic inequalities. Public Health Nutr. 2020, 23, 72–82. [Google Scholar] [CrossRef] [PubMed]
- Kapil, U. Integrated Child Development Services (ICDS) scheme: A program for holistic development of children in India. Indian J Pediatr. 2002, 69, 597–601. [Google Scholar] [CrossRef]
- Ruducha, J.; Bhatia, A.; Mann, C.; Torlesse, H. Multisectoral nutrition planning in Nepal: Evidence from an organizational network analysis. Matern Child Nutr. 2022, 18, e13112. [Google Scholar] [CrossRef] [PubMed]
- Tam, E.; Keats, E.C.; Rind, F.; Das, J.K.; Bhutta, Z.A. Micronutrient supplementation and fortification interventions on health and development outcomes among children under five in low- and middle-income countries: A systematic review and meta-analysis. Nutrients. 2020, 12, 289. [Google Scholar] [CrossRef]
- Perdomo, C.D.; Rodríguez, E.R.; Magallanes, H.C.; Flores Navarro, H.E.; Matul Pérez, S.E.; Moyano, D. Impact of a community program for child malnutrition. Rev Chil Pediatr. 2019, 90, 411–421. [Google Scholar] [CrossRef] [PubMed]
- Wells, J.C.; Sawaya, A.L.; Wibaek, R.; Mwangome, M.; Poullas, M.S.; Yajnik, C.S.; et al. The double burden of malnutrition: Aetiological pathways and consequences for health. Lancet 2020, 395, 75–88. [Google Scholar] [CrossRef] [PubMed]
| Target Group | Key Interventions |
|---|---|
| Pregnancy and Lactating Women | Antenatal and postnatal care and nutritional assessment Provision of energy-dense nutritious foods (LNS) Iron and folic acid supplementation Intensive nutrition counseling and behavioral change communication - Follow-ups |
| Birth to 6 months | Helping Baby Breathe Helping Baby Survive Promotion of exclusive breastfeeding Immunization Behavioral change communication (IYCF practices, care practices, hygiene, and sanitation) - Follow-ups |
| Children (6–23 months) | Promotion of continued breastfeeding Immunization Promotion of Infant and Young Child Feeding (IYCF) practices Provision of LNS and iron supplementation Growth monitoring Vitamin A supplementation Treatment of acute malnutrition (SAM and MAM) - Behavioral change communication (healthy diets, food demonstrations, care practices, hygiene, and sanitation) |
| Children (24–59 months) | Growth monitoring Improved hygiene and sanitation practices Treatment of acute malnutrition (SAM and MAM) with LNS and RUTF - Follow-ups- Behavioral change communication (healthy diets, care practices, hygiene, and sanitation) |
| Variable | Baseline (% (95 % CIs)) | Midline (% (95 % CIs)) |
| Household-level indicators | N=1022 | N=961 |
| Household Size; mean (95 % CIs) | 7.4 (7.2 - 7.6) | 7.5 (7.3 - 7.7) |
| SES Status | ||
| Poorest | 20.1% (17.6% - 22.6%) | 21.5% (18.6% - 24.4%) |
| Poor | 19.9% (17.4% - 22.4%) | 20.5% (17.7% - 23.4%) |
| Middle | 20.0% (17.5% - 22.6%) | 19.2% (16.5% - 21.9%) |
| Rich | 20.0% (17.4% - 22.6%) | 20.1% (17.3% - 22.9%) |
| Richest | 19.9% (17.4% - 22.5%) | 18.7% (16.1% - 21.3%) |
| Type of Housing | ||
| Flooring | ||
| Natural | 35.2% (32.2% - 38.2%) | 37.7% (34.3% - 41.1%) |
| Rudiment | 1.9% (1.0% - 2.8%) | 0.6% (0.1% - 1.0%) |
| Finished | 61.0% (57.9% - 64.0%) | 61.7% (58.3% - 65.1%) |
| Other | 1.9% (1.0% - 2.8%) | - |
| Roof | ||
| Natural roofing | 0.1% (0.0% - 0.4%) | 0.2% (0.0% - 0.4%) |
| Rudimentary roofing | 28.5% (25.6% - 31.5%) | 88.8% (86.7% - 90.8%) |
| Finished roofing | 41.9% (38.7% - 45.0%) | 11.1% (9.0% - 13.1%) |
| Other | 29.4% (26.6% - 32.3%) | - |
| Walls | ||
| Natural walls | 7.4% (5.8% - 9.0%) | 0.8% (0.2% - 1.4%) |
| Rudimentary walls | 41.1% (37.9% - 44.2%) | 33.8% (30.5% - 37.1%) |
| Finished walls | 50.5% (47.3% - 53.7%) | 65.4% (62.1% - 68.7%) |
| Other | 1.0% (0.3% - 1.7%) | - |
| Access to Safe Drinking Water (Improved sources of water) | 99.1% (98.4% - 99.8%) | 98.2% (97.3% - 99.1%) |
| Improved Sanitation Facilities | 96.8% (95.7% - 98.0%) | 99.0% (98.2% - 99.8%) |
| Food Security Status | N=1022 | N=961 |
| Food Secure | 95.2% (93.7% - 96.7%) | 11.9% (9.7% - 14.0%) |
| Mild Food Insecure | 1.3% (0.5% - 2.2%) | 36.6% (33.2% - 39.9%) |
| Moderate Food Insecure | 1.2% (0.4% - 1.9%) | 44.1% (40.6% - 47.5%) |
| Severely Food Insecure | 2.3% (1.3% - 3.4%) | 7.5% (5.7% - 9.3%) |
| Mothers level indicators | N=827 | N=1259 |
| Mother's Age Group | ||
| Less than 20 years | 2.3% (1.2% - 3.4%) | 2.7% (1.7% - 3.8%) |
| 20-34 years | 77.1% (74.1% - 80.2%) | 73.7% (71.0% - 76.4%) |
| 35-49 years | 20.6% (17.6% - 23.5%) | 23.6% (21.0% - 26.2%) |
| Mother's Education Level | ||
| Illiterate | 50.0% (46.4% - 53.6%) | 32.1% (29.2% - 34.9%) |
| Literate | 50.0% (46.4% - 53.6%) | 67.9% (65.1% - 70.8%) |
| Employment Status of Mother | ||
| Working | 4.9% (3.4% - 6.5%) | 5.2% (3.9% - 6.5%) |
| Not working | 95.1% (93.5% - 96.6%) | 94.8% (93.5% - 96.1%) |
| Father's Education Level | N=785 | N=1261 |
| Illiterate | 35.8% (32.3% - 39.4%) | 20.3% (17.8% - 22.8%) |
| Literate | 64.2% (60.6% - 67.7%) | 79.7% (77.2% - 82.2%) |
| Child level indicators | N=843 | N=1286 |
| Child's Sex | ||
| Male | 47.7% (44.2% - 51.3%) | 48.9% (45.9% - 51.9%) |
| Female | 52.3% (48.7% - 55.8%) | 51.1% (48.1% - 54.1%) |
| Child's Age Group | ||
| 0-5 months | 9.9% (7.8% - 12.1%) | 8.9% (7.1% - 10.6%) |
| 6-11 months | 9.2% (7.1% - 11.2%) | 9.9% (8.0% - 11.7%) |
| 12-23 months | 15.1% (12.6% - 17.7%) | 18.1% (15.8% - 20.4%) |
| 24-35 months | 25.6% (22.5% - 28.6%) | 23.4% (20.8% - 25.9%) |
| 36-47 months | 21.3% (18.4% - 24.3%) | 19.7% (17.3% - 22.1%) |
| 48-59 months | 18.8% (16.1% - 21.6%) | 20.1% (17.7% - 22.5%) |
| Child's Breastfeeding Status | N=80 | N=108 |
| 71.3% (61.3% - 81.3%) | 88.3% (81.7% - 95.0%) | |
| MDD (6-24 month) IYCF | N=207 | N=360 |
| 4.0% (1.2% - 6.8%) | 26.8% (21.9% - 31.8%) | |
| Immunization Status of Child (12-23 months of age) | N=126 | N=235 |
| Not immunized | - | 0.4% (0.0% -0.9%) |
| Partially immunized | - | 0.6% (0.0% - 1.4%) |
| Fully immunized | 100.0% (100.0% - 100.0%) | 99.1% (98.1% - 100.0%) |
|
Baseline-% (95 % CIs) |
N |
Midline-% (95 % CIs) |
N |
Midline-Baseline (% diff) (95 % CIs) |
P value |
Effect size Cohens h |
|
| Nutritional status | |||||||
| GBC | |||||||
| Underweight | 20.8% (18.0% - 23.7%) |
842 | 15.5% (13.3% - 17.7%) |
1275 | -5.4% (-9.0% - -1.8%) |
0.004 | 0.14 |
| Severely Underweight | 7.0% (5.3% - 8.8%) | 842 | 2.9% (1.9% - 3.9%) |
1275 | -4.2% (-6.2% - -2.1%) |
<0.001 | 0.19 |
| Stunted | 40.9% (37.2% - 44.5%) |
767 | 35.4% (32.5% - 38.2%) |
1271 | -5.5% (-10.2% - -0.9%) |
0.02 | 0.11 |
| Severely Stunted | 17.8% (15.0% - 20.5%) |
767 | 10.9% (9.0% - 12.7%) |
1271 | -6.9% (-10.3% - -3.6%) |
<0.001 | 0.20 |
| Wasted | 9.8% (7.6% - 12.0%) | 778 | 4.9% (3.5% - 6.2%) |
1270 | -5.0% (-7.5% - -2.4%) |
<0.001 | 0.19 |
| Severely Wasted | 5.0% (3.4% - 6.6%) | 778 | 1.5% (0.7% - 2.2%) | 1270 | -3.5% (-5.3% - -1.7%) | <0.001 | 0.21 |
| Concurrent Stunting & Wasting | 1.4% (0.6% - 2.2%) |
734 | 1.6% (0.8% - 2.4%) |
1266 | 0.2% (-0.9% - 1.3%) |
0.752 | 0.02 |
| Chitral | |||||||
| Underweight | 21.5% (18.0% - 24.9%) |
570 | 17.9% (14.9% - 20.9%) |
745 | -3.6% (-8.2% - 1.0%) |
0.125 | 0.09 |
| Severely Underweight | 8.4% (6.1% - 10.7%) |
570 | 3.7% (2.2% - 5.2%) |
745 | -4.7% (-7.4% - -1.9%) |
0.001 | 0.20 |
| Stunted | 46.0% (41.6% - 50.5%) |
512 | 38.8% (35.0% - 42.6%) |
743 | -7.2% (-13.1% - -1.4%) |
0.016 | 0.15 |
| Severely Stunted | 22.3% (18.6% - 26.0%) |
512 | 13.1% (10.4% - 15.7%) |
743 | -9.3% (-13.8% - -4.7%) |
<0.001 | 0.24 |
| Wasted | 10.9% (8.1% - 13.7%) |
527 | 5.1% (3.3% - 6.9%) |
743 | -5.8% (-9.1% - -2.5%) |
0.001 | 0.22 |
| Severely Wasted | 5.0% (3.0% - 7.0%) |
527 | 1.3% (0.4% - 2.3%) |
743 | -3.6% (-5.9% - -1.4%) |
0.001 | 0.22 |
| Concurrent Stunting & Wasting | 1.7% (0.6% - 2.9%) |
492 | 2.0% (0.9% - 3.2%) |
740 | 0.3% (-1.3% - 1.9%) |
0.694 | 0.02 |
| GB | |||||||
| Underweight | 19.8% (14.8% - 24.7%) |
272 | 11.9% (8.8% - 14.9%) |
530 | -7.9% (-13.7% - -2.1%) |
0.007 | 0.22 |
| Severely Underweight | 4.9% (2.3% - 7.5%) | 272 | 1.7% (0.6% - 2.7%) | 530 | -3.2% (-6.1% - -0.4%) |
0.026 | 0.18 |
| Stunted | 33.1% (27.0% - 39.2%) |
255 | 30.3% (25.9% - 34.6%) |
528 | -2.8% (-10.3% - 4.6%) |
0.456 | 0.06 |
| Severely Stunted | 10.9% (6.9% - 14.9%) |
255 | 7.6% (5.1% - 10.1%) |
528 | -3.3% (-8.0% - 1.4%) |
0.166 | 0.11 |
| Wasted | 8.2% (4.7% - 11.7%) |
251 | 4.6% (2.5% - 6.6%) |
527 | -3.6% (-7.7% - 0.4%) |
0.08 | 0.15 |
| Severely Wasted | 4.9% (2.2% - 7.7%) |
251 | 1.7% (0.5% - 2.9%) |
527 | -3.2% (-6.2% - -0.3%) |
0.031 | 0.18 |
| Concurrent Stunting & Wasting | 1.0% (-0.1% - 2.1%) |
242 | 1.0% (0.1% - 1.8%) |
526 | 0.0% (-1.4% - 1.4%) |
0.98 | 0.00 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).