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The Clinical Role of miRNAs in the Development and Treatment of Glioblastoma

Submitted:

03 February 2025

Posted:

04 February 2025

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Abstract
Glioblastoma multiforme (GBM) is the most common brain tumour and one of the most aggressive, with a median overall survival (OS) of only 15-18 months. These characteristics make it necessary to identify new targets for the improvement of prognosis and better prediction of response to therapies currently available for GBM patients. One possible candidate target could be the evaluation of miRNAs. miRNAs are small non-coding RNAs that play important roles in post-transcriptional gene regulation. Due to their functions, miRNAs also control biological processes underlying the development of GBM and may be considered as possible targets with a clinical role. This narrative review aims to introduce the concept of miRNAs in GBM from a clinical and a molecular perspective, and then addresses the specific miRNAs that are most described in the literature as relevant for the development, the prognosis and the response to therapies for patients affected by GBM.
Keywords: 
GBM; miRNAs; prognosis; survival; treatment; TMZ
Subject: 
Medicine and Pharmacology  -   Oncology and Oncogenics
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.

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