Version 1
: Received: 1 August 2024 / Approved: 1 August 2024 / Online: 4 August 2024 (16:30:28 CEST)
How to cite:
Nikolova, M.; Mandadzhieva, S.; Milova, N.; Milov, A.; Yordanov, A. Something Old, Something New, Something Borrowed … about the Placenta. Preprints2024, 2024080097. https://doi.org/10.20944/preprints202408.0097.v1
Nikolova, M.; Mandadzhieva, S.; Milova, N.; Milov, A.; Yordanov, A. Something Old, Something New, Something Borrowed … about the Placenta. Preprints 2024, 2024080097. https://doi.org/10.20944/preprints202408.0097.v1
Nikolova, M.; Mandadzhieva, S.; Milova, N.; Milov, A.; Yordanov, A. Something Old, Something New, Something Borrowed … about the Placenta. Preprints2024, 2024080097. https://doi.org/10.20944/preprints202408.0097.v1
APA Style
Nikolova, M., Mandadzhieva, S., Milova, N., Milov, A., & Yordanov, A. (2024). Something Old, Something New, Something Borrowed … about the Placenta. Preprints. https://doi.org/10.20944/preprints202408.0097.v1
Chicago/Turabian Style
Nikolova, M., Antoan Milov and Angel Yordanov. 2024 "Something Old, Something New, Something Borrowed … about the Placenta" Preprints. https://doi.org/10.20944/preprints202408.0097.v1
Abstract
The connection between the mother and the child has been considered one of the strongest bonds in nature. Though there are numerous factors that can influence the establishment of pregnancy, in its essence three are considered major: a good quality embryo, a receptive endometrium and a successful cross-talk between them. The placenta, that derives from the trophoblast of the embryo, develops when a successful implantation occurs. It is an ephemeral organ through which the turnover of nutrient, gas and waste molecules is realized. It serves as barrier and can provide the embryo with immune factors. Placental disorders are observed in some rare but life-threatening obstetric conditions like: preeclampsia (PE), fetal growth restriction (FGR), gestational tropho-blastic diseases (GTD) and gestational diabetes mellitus (GDM). The etiology and pathogenesis of some are still partially enigmatic. Our attention in this review was driven by the participation of small RNA molecules: miRNAs and piRNAs, as potential epigenetic modulators of genes that play pivotal role in placental functioning. The molecular approach for understanding of placental disorders may help new diagnostic and therapeutic solutions to be found.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
