Version 1
: Received: 23 May 2024 / Approved: 24 May 2024 / Online: 24 May 2024 (08:38:37 CEST)
How to cite:
Vicenti, C.; Romagnoli, N.; Stabile, M.; Lambertini, C.; Piemontese, C.; Spaccini, F.; Foglia, A.; Lacitignola, L.; Crovace, A.; Staffieri, F. Pleth Variability Index as a Guide to Fluid Therapy in Dogs Undergoing General Anesthesia: A Preliminary Study. Preprints2024, 2024051599. https://doi.org/10.20944/preprints202405.1599.v1
Vicenti, C.; Romagnoli, N.; Stabile, M.; Lambertini, C.; Piemontese, C.; Spaccini, F.; Foglia, A.; Lacitignola, L.; Crovace, A.; Staffieri, F. Pleth Variability Index as a Guide to Fluid Therapy in Dogs Undergoing General Anesthesia: A Preliminary Study. Preprints 2024, 2024051599. https://doi.org/10.20944/preprints202405.1599.v1
Vicenti, C.; Romagnoli, N.; Stabile, M.; Lambertini, C.; Piemontese, C.; Spaccini, F.; Foglia, A.; Lacitignola, L.; Crovace, A.; Staffieri, F. Pleth Variability Index as a Guide to Fluid Therapy in Dogs Undergoing General Anesthesia: A Preliminary Study. Preprints2024, 2024051599. https://doi.org/10.20944/preprints202405.1599.v1
APA Style
Vicenti, C., Romagnoli, N., Stabile, M., Lambertini, C., Piemontese, C., Spaccini, F., Foglia, A., Lacitignola, L., Crovace, A., & Staffieri, F. (2024). Pleth Variability Index as a Guide to Fluid Therapy in Dogs Undergoing General Anesthesia: A Preliminary Study. Preprints. https://doi.org/10.20944/preprints202405.1599.v1
Chicago/Turabian Style
Vicenti, C., Antonio Crovace and Francesco Staffieri. 2024 "Pleth Variability Index as a Guide to Fluid Therapy in Dogs Undergoing General Anesthesia: A Preliminary Study" Preprints. https://doi.org/10.20944/preprints202405.1599.v1
Abstract
The aim of this prospective, randomized, clinical study was to evaluate the use of the pleth variability index (PVi) to guide the rate of intra-operative fluid therapy as compared with a traditional fixed fluid rate approach in ASA 1-2 dogs undergoing surgery. Twenty-seven dogs meet the inclusion criteria and were randomly assigned to conventional fluid management group (CFM, n = 12) or PVi-guided group (PVi, n = 15). The CFM group received a fixed rate of 5 ml kg-1 h-1 of crystalloid solution, while in the PVi group the rate was continuously adjusted based on PVi: PVi < 14% = 3 ml kg-1 h-1; 14% ≤ PVi ≥ 20% = ml kg-1 h-1; PVi > 20% = 15 ml kg-1 h-1. Hypotension (MAP < 65 mmHg) was managed in CFM with maximum two fluid boluses (5 ml kg-1 in 10 minutes) and in case of no response dobutamine (1-3 mcg kg-1 min-1) was administered. In the PVi group treatment of hypotension was similar except when PVi > 14% when dobutamine was directly initiated. The total fluid amount was significantly lower in PVI group (0.056 ± 0.027 ml kg-1 min-1) vs. CFM group (0.132 ± 0.115 ml kg-1 min-1), and hypotension incidence was lower (p = 0.023) in PVi group (0%) vs. CFM group (41%). Mean arterial pressure (MAP) was significantly higher during surgery in the PVi group. Dobutamine was never administered in both groups. Preliminary data suggest that PVi may be considered a potential target to guide fluid therapy in dogs; larger studies are needed, especially in cases of cardiovascular instability.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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