Version 1
: Received: 15 May 2024 / Approved: 15 May 2024 / Online: 15 May 2024 (11:38:58 CEST)
How to cite:
Wang, S. S. Y.; Gallardo, C.; Tang, H.; Lim, E. K. G.; Christopher, D.; Fan, B. E.; Ponnudurai, K. Two Unusual Cases of Thrombotic Microangiopathies. Preprints2024, 2024051033. https://doi.org/10.20944/preprints202405.1033.v1
Wang, S. S. Y.; Gallardo, C.; Tang, H.; Lim, E. K. G.; Christopher, D.; Fan, B. E.; Ponnudurai, K. Two Unusual Cases of Thrombotic Microangiopathies. Preprints 2024, 2024051033. https://doi.org/10.20944/preprints202405.1033.v1
Wang, S. S. Y.; Gallardo, C.; Tang, H.; Lim, E. K. G.; Christopher, D.; Fan, B. E.; Ponnudurai, K. Two Unusual Cases of Thrombotic Microangiopathies. Preprints2024, 2024051033. https://doi.org/10.20944/preprints202405.1033.v1
APA Style
Wang, S. S. Y., Gallardo, C., Tang, H., Lim, E. K. G., Christopher, D., Fan, B. E., & Ponnudurai, K. (2024). Two Unusual Cases of Thrombotic Microangiopathies. Preprints. https://doi.org/10.20944/preprints202405.1033.v1
Chicago/Turabian Style
Wang, S. S. Y., Bingwen Eugene Fan and Kuperan Ponnudurai. 2024 "Two Unusual Cases of Thrombotic Microangiopathies" Preprints. https://doi.org/10.20944/preprints202405.1033.v1
Abstract
Thrombotic microangiopathies (TMA) can be attributed to a wide variety of causes and the diagnostic process is often challenging, especially when the clinical scenario is full of other confounding factors. Hemolysis can be due to complement-mediated thrombotic microangiopathies and drug-induced hemolytic anemia in the appropriate clinical context. In this case presentation, two patients with TMA including a patient diagnosed with complement-mediated TMA after a through screen of other differential diagnoses, and a multiple myeloma patient on chemotherapy with primaquine-induced hemolytic anemia in the background of treatment for possible pneumocystis jirovecii pneumonia. A thorough review of the drug history of patients presenting with TMA should be conducted, along with a heightened index of suspicion for complement-mediated disorders such as complement-mediated TMA, which should be entertained after ruling out a wide variety of differential diagnoses.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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