Version 1
: Received: 8 May 2024 / Approved: 8 May 2024 / Online: 9 May 2024 (02:57:19 CEST)
How to cite:
De Silva, A. P.; Nuwanshika, N.; Niriella, M. A.; De Silva, J. H. Gilbert’s Syndrome: The Good, the Bad and the Ugly. Preprints2024, 2024050500. https://doi.org/10.20944/preprints202405.0500.v1
De Silva, A. P.; Nuwanshika, N.; Niriella, M. A.; De Silva, J. H. Gilbert’s Syndrome: The Good, the Bad and the Ugly. Preprints 2024, 2024050500. https://doi.org/10.20944/preprints202405.0500.v1
De Silva, A. P.; Nuwanshika, N.; Niriella, M. A.; De Silva, J. H. Gilbert’s Syndrome: The Good, the Bad and the Ugly. Preprints2024, 2024050500. https://doi.org/10.20944/preprints202405.0500.v1
APA Style
De Silva, A. P., Nuwanshika, N., Niriella, M. A., & De Silva, J. H. (2024). Gilbert’s Syndrome: The Good, the Bad and the Ugly. Preprints. https://doi.org/10.20944/preprints202405.0500.v1
Chicago/Turabian Style
De Silva, A. P., Madunil A Niriella and Janaka H De Silva. 2024 "Gilbert’s Syndrome: The Good, the Bad and the Ugly" Preprints. https://doi.org/10.20944/preprints202405.0500.v1
Abstract
Gilbert's syndrome (GS) is a common hereditary condition characterized by mild increases in serum bilirubin levels due to inherited defects in bilirubin metabolism. This review, based on data from peer-reviewed articles and journals spanning from 1977 to January 2024, provides a comprehensive overview of over four decades of research on GS. Early studies primarily focused on defining the clinical and genetic characteristics of the syndrome, laying the foundation for subsequent investigations. More recent research has delved into the genetic mechanisms underlying the reduced expression of bilirubin UDP-glucuronosyltransferase, which has significantly enhanced our understanding of the pathogenesis of GS. Furthermore, recent studies have shed light on the clinical implications of GS, including its association with non-alcoholic fatty liver disease and mortality risk, highlighting the complex interplay between genetic factors, bilirubin metabolism, and clinical outcomes. Despite its generally benign nature, thorough research is essential to fully understand the impact of GS on patients' lives. This review emphasizes the importance of ongoing research to deepen our understanding of GS and its broader implications.
Keywords
Gilbert’s syndrome (GS), Genetic variations, Protective effects of Gilbert’s syndrome, Cancer risk, Drug interactions, Pharmacokinetic abnormalities, Clinical implications of Gilbert’s Syndrome, Effect on NASH, Liver transplantation, Psychology and GS
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
