Review
Version 1
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Iron Metabolism in the Recovery Phase of Critical Illness
Version 1
: Received: 7 May 2024 / Approved: 7 May 2024 / Online: 7 May 2024 (11:43:07 CEST)
How to cite: Zhang, X.; Holbein, B.; Zhou, J.; Lehmann, C. Iron Metabolism in the Recovery Phase of Critical Illness. Preprints 2024, 2024050375. https://doi.org/10.20944/preprints202405.0375.v1 Zhang, X.; Holbein, B.; Zhou, J.; Lehmann, C. Iron Metabolism in the Recovery Phase of Critical Illness. Preprints 2024, 2024050375. https://doi.org/10.20944/preprints202405.0375.v1
Abstract
Iron is an essential nutrient for humans and microbes, such as bacteria. Iron deficiency occurs commonly in critically ill patients, but iron replacement therapy is not considered during the acute phase of critical illness, since it increases iron availability for invading microbes and oxidative stress. However, persistent iron deficiency in the recovery phase is harmful with potential adverse outcomes such as cognitive dysfunction, fatigue and cardiopulmonary dysfunction. Therefore, it is important to treat iron deficiency timely and efficiently. This article reviews current knowledge about iron-related biomarkers in critically ill patients and provides possible criteria to guide decision-making for iron supplementation in the recovery phase of critical illness.
Keywords
critical illness; iron deficiency; recovery; iron supplementation
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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